Literature DB >> 10940046

The rel gene is essential for in vitro growth of Staphylococcus aureus.

D Gentry1, T Li, M Rosenberg, D McDevitt.   

Abstract

The stringent response in Staphylococcus aureus is mediated by the nucleotide guanosine pentaphosphate, whose synthesis is catalyzed by the product of the rel gene. We report here that the rel gene is essential for the in vitro growth of S. aureus, distinguishing it from all other bacteria tested for this requirement.

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Year:  2000        PMID： 10940046      PMCID： PMC111382          DOI： 10.1128/JB.182.17.4995-4997.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  16 in total

1.  Streptomyces ATP nucleotide 3'-pyrophosphokinase and its gene.

Authors:  S Muta; K Osoegawa; S Ezaki; M Zubair; S Kuhara; J Mukai; R Dixon
Journal:  Nucleic Acids Symp Ser       Date:  1992

2.  Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.

Authors:  H Xiao; M Kalman; K Ikehara; S Zemel; G Glaser; M Cashel
Journal:  J Biol Chem       Date:  1991-03-25       Impact factor: 5.157

3.  A rapid test for the rel A mutation in E. coli.

Authors:  M Uzan; A Danchin
Journal:  Biochem Biophys Res Commun       Date:  1976-04-05       Impact factor: 3.575

4.  Analysis of two chloramphenicol resistance plasmids from Staphylococcus aureus: insertional inactivation of Cm resistance, mapping of restriction sites, and construction of cloning vehicles.

Authors:  C R Wilson; S E Skinner; W V Shaw
Journal:  Plasmid       Date:  1981-05       Impact factor: 3.466

5.  Guanosine pentaphosphate synthetase from Streptomyces antibioticus is also a polynucleotide phosphorylase.

Authors:  G H Jones; M J Bibb
Journal:  J Bacteriol       Date:  1996-07       Impact factor: 3.490

6.  Escherichia coli ppGpp synthetase II activity requires spoT.

Authors:  V J Hernandez; H Bremer
Journal:  J Biol Chem       Date:  1991-03-25       Impact factor: 5.157

7.  Cloning and characterization of a bifunctional RelA/SpoT homologue from Mycobacterium tuberculosis.

Authors:  D Avarbock; J Salem; L S Li; Z M Wang; H Rubin
Journal:  Gene       Date:  1999-06-11       Impact factor: 3.688

8.  Cloning the spoT gene of Escherichia coli: identification of the spoT gene product.

Authors:  G An; J Justesen; R J Watson; J D Friesen
Journal:  J Bacteriol       Date:  1979-03       Impact factor: 3.490

9.  Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci.

Authors:  R Cassels; B Oliva; D Knowles
Journal:  J Bacteriol       Date:  1995-09       Impact factor: 3.490

10.  Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis.

Authors:  U Mechold; M Cashel; K Steiner; D Gentry; H Malke
Journal:  J Bacteriol       Date:  1996-03       Impact factor: 3.490
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  18 in total

Review 1.  ppGpp conjures bacterial virulence.

Authors:  Zachary D Dalebroux; Sarah L Svensson; Erin C Gaynor; Michele S Swanson
Journal:  Microbiol Mol Biol Rev       Date:  2010-06       Impact factor: 11.056

2.  Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover.

Authors:  Kelsi L Anderson; Christelle M Roux; Matthew W Olson; Thanh T Luong; Chia Y Lee; Robert Olson; Paul M Dunman
Journal:  FEMS Immunol Med Microbiol       Date:  2010-10-06

3.  Whole-genome sequencing reveals a link between β-lactam resistance and synthetases of the alarmone (p)ppGpp in Staphylococcus aureus.

Authors:  Michael M Mwangi; Choonkeun Kim; Marilyn Chung; Jennifer Tsai; Govindan Vijayadamodar; Michelle Benitez; Thomas P Jarvie; Lei Du; Alexander Tomasz
Journal:  Microb Drug Resist       Date:  2013-05-09       Impact factor: 3.431

4.  Borrelia burgdorferi rel is responsible for generation of guanosine-3'-diphosphate-5'-triphosphate and growth control.

Authors:  Julia V Bugrysheva; Anton V Bryksin; Henry P Godfrey; Felipe C Cabello
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

5.  Two small (p)ppGpp synthases in Staphylococcus aureus mediate tolerance against cell envelope stress conditions.

Authors:  Tobias Geiger; Benjamin Kästle; Fabio Lino Gratani; Christiane Goerke; Christiane Wolz
Journal:  J Bacteriol       Date:  2013-12-13       Impact factor: 3.490

6.  Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus.

Authors:  Tobias Geiger; Christiane Goerke; Michaela Fritz; Tina Schäfer; Knut Ohlsen; Manuel Liebeke; Michael Lalk; Christiane Wolz
Journal:  Infect Immun       Date:  2010-03-08       Impact factor: 3.441

7.  Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilis.

Authors:  Undine Mechold; Helen Murphy; Larissa Brown; Michael Cashel
Journal:  J Bacteriol       Date:  2002-06       Impact factor: 3.490

8.  Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.

Authors:  Wei Gao; Kyra Chua; John K Davies; Hayley J Newton; Torsten Seemann; Paul F Harrison; Natasha E Holmes; Hyun-Woo Rhee; Jong-In Hong; Elizabeth L Hartland; Timothy P Stinear; Benjamin P Howden
Journal:  PLoS Pathog       Date:  2010-06-10       Impact factor: 6.823

9.  The fusidic acid stimulon of Staphylococcus aureus.

Authors:  Alejandro Delgado; Shahrear Zaman; Arunachalam Muthaiyan; Vijayaraj Nagarajan; Mohamed O Elasri; Brian J Wilkinson; John E Gustafson
Journal:  J Antimicrob Chemother       Date:  2008-09-10       Impact factor: 5.790

10.  Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH).

Authors:  Roy R Chaudhuri; Andrew G Allen; Paul J Owen; Gil Shalom; Karl Stone; Marcus Harrison; Timothy A Burgis; Michael Lockyer; Jorge Garcia-Lara; Simon J Foster; Stephen J Pleasance; Sarah E Peters; Duncan J Maskell; Ian G Charles
Journal:  BMC Genomics       Date:  2009-07-01       Impact factor: 3.969
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