Literature DB >> 10937734

Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.

M Patel1, R J McHugh, B C Cordova, R M Klabe, S Erickson-Viitanen, G L Trainor, J D Rodgers.   

Abstract

A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopropylmethyl (6a, 6g, 6h, and 6k) and N-carboalkoxy (6m-6y) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X.

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Year:  2000        PMID： 10937734     DOI： 10.1016/s0960-894x(00)00321-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes.

Authors:  Zhigang Xu; Arthur Y Shaw; Gary S Nichol; Alexandra P Cappelli; Christopher Hulme
Journal:  Mol Divers       Date:  2012-05-24       Impact factor: 2.943

2.  Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities.

Authors:  Mahesh S; Boya Palajonnala Narasaiah; Himabindu B; Balaji G L; Jangampalli Adi Pradeepkiran; Harihara Padhy
Journal:  Antioxidants (Basel)       Date:  2022-03-31

3.  2,3-Bis(4-bromo-phen-yl)quinoxaline.

Authors:  Fang-Fang Jian; Ke-Fei Wang; Rui-Rui Zhuang; Hai-Lian Xiao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

4.  New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities.

Authors:  Carlos Barea; Adriana Pabón; Silvia Pérez-Silanes; Silvia Galiano; German Gonzalez; Antonio Monge; Eric Deharo; Ignacio Aldana
Journal:  Molecules       Date:  2013-04-22       Impact factor: 4.411
  4 in total

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