Literature DB >> 10937723

Efficient synthesis of 8-oxo-dGTP: a mutagenic nucleotide.

S Nampalli1, S Kumar.   

Abstract

An efficient synthesis of mutagenic and oxidative DNA damage product, 8-oxo-dGTP (4) has been achieved in high yield, along with a serendipitous generation of 8-dimsyl-dG (2). In combination with dPTP (5), 8-oxo-dGTP (4) can be formulated into a kit for investigating DNA random mutagenesis.

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Year:  2000        PMID： 10937723     DOI： 10.1016/s0960-894x(00)00310-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis and thermodynamic studies of oligodeoxyribonucleotides containing tandem lesions of thymidine glycol and 8-oxo-2'-deoxyguanosine.

Authors:  Yuesong Wang; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2006-06       Impact factor: 3.739

2.  Facile photocyclization chemistry of 5-phenylthio-2'-deoxyuridine in duplex DNA.

Authors:  Yu Zeng; Huachuan Cao; Yinsheng Wang
Journal:  Org Lett       Date:  2006-06-08       Impact factor: 6.005

3.  Identification and quantification of a guanine-thymine intrastrand cross-link lesion induced by Cu(II)/H2O2/ascorbate.

Authors:  Haizheng Hong; Huachuan Cao; Yuesong Wang; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2006-05       Impact factor: 3.739

4.  Synthesis of 8-oxo-dGTP and its β,γ-CH2-, β, γ-CHF-, and β, γ-CF2- analogues.

Authors:  Yiying Zheng; Pouya Haratipour; Boris A Kashemirov; Charles E McKenna
Journal:  Tetrahedron Lett       Date:  2021-02-04       Impact factor: 2.415
  4 in total

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