Literature DB >> 10937710

Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones.

P G Nantermet1, J C Barrow, H G Selnick, C F Homnick, R M Freidinger, R S Chang, S S O'Malley, D R Reiss, T P Broten, R W Ransom, D J Pettibone, T Olah, C Forray.   

Abstract

A series of alpha1a receptor antagonists derived from a 4-aryl-3,4-dihydropyridine-2-one heterocycle is disclosed. Potency in the low nanomolar to picomolar range along with high selectivity was obtained. In vivo efficacy in a prostate contraction model in rats was observed with a few derivatives.

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Year:  2000        PMID： 10937710     DOI： 10.1016/s0960-894x(99)00696-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes.

Authors:  Rakesh Kumar; Neha Yadav; Rodolfo Lavilla; Daniel Blasi; Jordi Quintana; José Manuel Brea; María Isabel Loza; Jordi Mestres; Mamta Bhandari; Ritu Arora; Rita Kakkar; Ashok K Prasad
Journal:  Mol Divers       Date:  2017-04-25       Impact factor: 2.943

Review 2.  Asymmetric Organocatalysis: The Emerging Utility of α,β-Unsaturated Acylammonium Salts.

Authors:  Sreekumar Vellalath; Daniel Romo
Journal:  Angew Chem Int Ed Engl       Date:  2016-09-21       Impact factor: 15.336

3.  N-heterocyclic-carbene-catalyzed asymmetric oxidative hetero-Diels-Alder reactions with simple aliphatic aldehydes.

Authors:  Xiaodan Zhao; Kyle E Ruhl; Tomislav Rovis
Journal:  Angew Chem Int Ed Engl       Date:  2012-11-04       Impact factor: 15.336

4.  Benign prostatic hyperplasia: An overview of existing treatment.

Authors:  Neelima Dhingra; Deepak Bhagwat
Journal:  Indian J Pharmacol       Date:  2011-02       Impact factor: 1.200

5.  Enantioselective Synthesis of 3,5,6-Substituted Dihydropyranones and Dihydropyridinones using Isothiourea-Mediated Catalysis.

Authors:  Daniel G Stark; Louis C Morrill; David B Cordes; Alexandra M Z Slawin; Timothy J C O'Riordan; Andrew D Smith
Journal:  Chem Asian J       Date:  2015-11-12

6.  Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds.

Authors:  Martins Rucins; Rufus Smits; Anda Sipola; Brigita Vigante; Ilona Domracheva; Baiba Turovska; Ruslan Muhamadejev; Karlis Pajuste; Mara Plotniece; Arkadij Sobolev; Gunars Duburs; Aiva Plotniece
Journal:  Oxid Med Cell Longev       Date:  2020-12-31       Impact factor: 6.543

Review 7.  3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance.

Authors:  Sisa Chalán-Gualán; Vida Castro; Ruth Oropeza; Margarita Suárez; Fernando Albericio; Hortensia Rodríguez
Journal:  Molecules       Date:  2022-08-09       Impact factor: 4.927
  7 in total

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