The interferon regulatory factors and oncogenesis.

We study a family of transcription factors, the interferon regulatory factors (IRFs), as originally identified in the context of the regulation of type-I interferon (IFN-alpha/beta) system. Most notably, studies on IRF-1 have revealed its remarkable functional diversity in the regulation of cellular responses of host defense, including oncogenesis. The IRF family has now expanded to nine members, and gene disruption studies have revealed critical involvement of some of the members in the regulation of cell growth and oncogenesis. In this review, we summarize our current knowledge on the involvement of members of the IRF family members, in particular, IRF-1, in oncogenesis.