Literature DB >> 10935937

Investigation of an acute chemical incident: exposure to fluorinated hydrocarbons.

R A Lyons1, D Wright, H M Fielder, M McCabe, A Gunneberg, P Nash, P Routledge, H Rees.   

Abstract

OBJECTIVES: To assess whether attendance at the site after an incident in a sewer was associated with symptoms in emergency personnel and whether the prevalence of symptoms was associated with estimated levels of exposure to any chemical hazard.
METHODS: Symptoms experienced by people attending an incident involving two dead sewer workers suggested the presence of a chemical hazard, before environmental sampling confirmed any toxic agent. Self reported symptoms, estimated exposures, and biomarkers of exposure for likely agents from all 254 people who attended the incident and a referent occupational group matching the 83 emergency personnel who went to the Accident and Emergency department (A and E) in the first 48 hours were recorded. The prevalence of symptoms and concentrations of creatine phosphokinase in serum of the 83 early patients at A and E were compared with their referent occupational group. In all workers who attended the incident, the trends in symptom prevalences and concentrations of creatine phosphokinase in serum were examined by distance from the site and predefined exposure category.
RESULTS: Among all workers who attended the incident, symptoms of shortness of breath and sore throat were significantly associated with indirect estimates of exposure but not associated with concentrations of creatine phosphokinase. Freon was detected in two blood samples. The early patients at A and E reported more symptoms than their matched reference group and their median concentrations of creatine phosphokinase were higher.
CONCLUSIONS: The association between symptoms and concentrations of creatine phosphokinase with attendance at the site indicated the presence of a continuing hazard at the site and led to extra precautions being taken. Comparison values from the referent occupational group prevented unnecessary medical follow up.

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Year:  2000        PMID: 10935937      PMCID: PMC1740011          DOI: 10.1136/oem.57.9.577

Source DB:  PubMed          Journal:  Occup Environ Med        ISSN: 1351-0711            Impact factor:   4.402


  11 in total

1.  Episode of toxic gas exposure in sewer workers.

Authors:  M M Watt; S J Watt; A Seaton
Journal:  Occup Environ Med       Date:  1997-04       Impact factor: 4.402

2.  Illness associated with contamination of drinking water supplies with phenol.

Authors:  S N Jarvis; R C Straube; A L Williams; C L Bartlett
Journal:  Br Med J (Clin Res Ed)       Date:  1985-06-15

3.  Firefighting and malignant hyperthermia.

Authors:  M A Denborough; K C Hopkinson; D G Banney
Journal:  Br Med J (Clin Res Ed)       Date:  1988-05-21

4.  Fatal accidental inhalation of bromochlorodifluoromethane (Halon 1211).

Authors:  Y Lerman; E Winkler; M S Tirosh; Y Danon; S Almog
Journal:  Hum Exp Toxicol       Date:  1991-03       Impact factor: 2.903

5.  Elevated serum cardiac markers in asymptomatic marathon runners after competition: is the myocardium stunned?

Authors:  A J Siegel; M Sholar; J Yang; E Dhanak; K B Lewandrowski
Journal:  Cardiology       Date:  1997 Nov-Dec       Impact factor: 1.869

6.  Dehalogenation of trichlorofluoromethane (CFC-11) by Methanosarcina barkeri.

Authors:  U E Krone; R K Thauer
Journal:  FEMS Microbiol Lett       Date:  1992-01-01       Impact factor: 2.742

7.  Health effects of Halon 1301 exposure.

Authors:  D L Holness; R A House
Journal:  J Occup Med       Date:  1992-07

8.  Cancer among a Michigan cohort exposed to polybrominated biphenyls in 1973.

Authors:  A Hoque; A J Sigurdson; K D Burau; H E Humphrey; K R Hess; A M Sweeney
Journal:  Epidemiology       Date:  1998-07       Impact factor: 4.822

9.  Freon inhalational abuse presenting with ventricular fibrillation.

Authors:  W J Brady; E Stremski; L Eljaiek; T P Aufderheide
Journal:  Am J Emerg Med       Date:  1994-09       Impact factor: 2.469

10.  Thetford plastics fire, October 1991: the role of a preventive medical team in chemical incidents.

Authors:  P J Baxter; B J Heap; M G Rowland; V S Murray
Journal:  Occup Environ Med       Date:  1995-10       Impact factor: 4.402

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  4 in total

Review 1.  Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat).

Authors:  Bertold Renner; Christian A Mueller; Adrian Shephard
Journal:  Inflamm Res       Date:  2012-08-14       Impact factor: 4.575

2.  Integrated exposure assessment of sewage workers to genotoxicants: an urinary biomarker approach and oxidative stress evaluation.

Authors:  Hamzeh Al Zabadi; Luc Ferrari; Irène Sari-Minodier; Marie-Aude Kerautret; Aziz Tiberguent; Christophe Paris; Denis Zmirou-Navier
Journal:  Environ Health       Date:  2011-03-24       Impact factor: 5.984

Review 3.  Management of chemically contaminated bodies.

Authors:  Adrienne Edkins; Virginia Murray
Journal:  J R Soc Med       Date:  2005-04       Impact factor: 18.000

4.  Building national public health capacity for managing chemical events: a case study of the development of health protection services in the United Kingdom.

Authors:  Stephen Palmer; Gary Coleman
Journal:  J Public Health Policy       Date:  2013-02-28       Impact factor: 2.222

  4 in total

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