Literature DB >> 10935838

Occurrence of thyroid autoimmunity in relapsing remitting multiple sclerosis patients undergoing interferon-beta treatment.

V Martinelli1, M Gironi, M Rodegher, G Martino, G Comi.   

Abstract

We analyzed the titer of antithyroid autoantibodies (Abs) and thyroid function in 17 multiple sclerosis (MS) patients undergoing interferon-beta (IFN-beta) treatment and in 40 MS control patients. Basal evaluation revealed normal thyroid function in all patients. Abs were detected in 5 IFN-beta-treated patients (29%) and in 4 MS control patients (10%). Our results indicate that IFN-beta treatment may lead to thyroid autoimmunity. We therefore recommend periodic evaluations of antithyroid Abs and thyroid functionality in IFN-beta-treated MS patients.

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Year:  1998        PMID： 10935838     DOI： 10.1007/bf02427558

Source DB:  PubMed          Journal:  Ital J Neurol Sci        ISSN： 0392-0461


  16 in total

1.  IMMUNOLOGICAL STUDIES IN MULTIPLE SCLEROSIS: INCIDENCE OF CIRCULATING ANTIBODIES TO DIETARY PROTEINS AND AUTO-ANTIGENS.

Authors:  R WRIGHT; J A MORTON; K B TAYLOR
Journal:  Br Med J       Date:  1965-02-20

2.  [A case of chronic hepatitis complicated by subacute thyroiditis during beta-interferon treatment].

Authors:  S Tanabashi; Y Kawase; M Ukita; J Shiroko; M Kametani; H Kumada
Journal:  Nihon Shokakibyo Gakkai Zasshi       Date:  1996-07

3.  Multiple sclerosis and autoimmune diseases.

Authors:  H W Baker; J I Balla; H G Burger; P Ebeling; I R Mackay
Journal:  Aust N Z J Med       Date:  1972-08

4.  Antithyroid antibodies in multiple sclerosis.

Authors:  W R Kiessling; K W Pflughaupt
Journal:  Lancet       Date:  1980-01-05       Impact factor: 79.321

5.  Longitudinal study of antibodies against thyroid in patients undergoing interferon-alpha therapy for HCV chronic hepatitis.

Authors:  C Carella; G Amato; B Biondi; M Rotondi; F Morisco; C Tuccillo; N Chiuchiolo; G Signoriello; N Caporaso; G Lombardi
Journal:  Horm Res       Date:  1995

6.  Multiple sclerosis and other immunologic diseases.

Authors:  S Seyfert; P Klapps; C Meisel; T Fischer; U Junghan
Journal:  Acta Neurol Scand       Date:  1990-01       Impact factor: 3.209

7.  [Dysthyroidism in patients treated with interferon alpha].

Authors:  P Chédin; P Chanson; L Duranteau; P J Guillausseau; J Lubetzki
Journal:  Presse Med       Date:  1994-11-19       Impact factor: 1.228

8.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Authors:  T R Mosmann; H Cherwinski; M W Bond; M A Giedlin; R L Coffman
Journal:  J Immunol       Date:  1986-04-01       Impact factor: 5.422

9.  Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells.

Authors:  F Erard; M T Wild; J A Garcia-Sanz; G Le Gros
Journal:  Science       Date:  1993-06-18       Impact factor: 47.728

10.  Selective expression of an interleukin-12 receptor component by human T helper 1 cells.

Authors:  L Rogge; L Barberis-Maino; M Biffi; N Passini; D H Presky; U Gubler; F Sinigaglia
Journal:  J Exp Med       Date:  1997-03-03       Impact factor: 14.307
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  2 in total

1.  Long-term treatment with interferon-beta therapy for multiple sclerosis and occurrence of Graves' disease.

Authors:  M Rotondi; G Mazziotti; B Biondi; G Manganella; A D Del Buono; P Montella; M di Cristofaro; G Di Iorio; G Amato; C Carella
Journal:  J Endocrinol Invest       Date:  2000-05       Impact factor: 4.256

Review 2.  [Autoimmune functional disorders of the thyroid during interferon-beta-1b treatment in patients with multiple sclerosis. Case report and literature review].

Authors:  C Lange-Asschenfeldt; S Boor; G J Kahaly; F Thömke
Journal:  Nervenarzt       Date:  2004-06       Impact factor: 1.214
  2 in total

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