| Literature DB >> 10935021 |
Abstract
Cyclin D1 is a critical component of the core cell cycle machinery. Mice lacking cyclin D1 develop mammary glands that fail to undergo normal lobuloalveolar proliferation during pregnancy. Thus, cyclin D1 seems to play a critical role in pregnancy-induced proliferation of mammary epithelium. Cyclin D1 also participates in neoplasia, as the majority of human mammary carcinomas contain elevated levels of this cyclin.Entities:
Mesh:
Substances:
Year: 1997 PMID: 10935021 DOI: 10.1023/a:1026391128117
Source DB: PubMed Journal: J Mammary Gland Biol Neoplasia ISSN: 1083-3021 Impact factor: 2.673