Literature DB >> 10934664

Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.

L J Lesko1, M Rowland, C C Peck, T F Blaschke.   

Abstract

Two international meetings were convened in 1998 to review the current science of drug development and the potential opportunities to optimize the evaluation of new drugs in humans. This report represents a synopsis of these meetings, and focuses on the current state of knowledge pertaining to drug development, future scientific and technical needs, and the relative merits of various strategies intended to accelerate the clinical development of drugs.

Entities:  

Mesh：

Year:  2000        PMID： 10934664     DOI： 10.1177/00912700022009530

Source DB:  PubMed          Journal:  J Clin Pharmacol        ISSN： 0091-2700            Impact factor:   3.126


  6 in total

Review 1.  Quantitative clinical pharmacology is transforming drug regulation.

Authors:  Carl C Peck
Journal:  J Pharmacokinet Pharmacodyn       Date:  2010-10-27       Impact factor: 2.745

2.  Prediction discrepancies for the evaluation of nonlinear mixed-effects models.

Authors:  France Mentré; Sylvie Escolano
Journal:  J Pharmacokinet Pharmacodyn       Date:  2005-11-13       Impact factor: 2.745

Review 3.  Moving from basic toward systems pharmacodynamic models.

Authors:  William J Jusko
Journal:  J Pharm Sci       Date:  2013-05-16       Impact factor: 3.534

Review 4.  The role of fMRI in drug development.

Authors:  Owen Carmichael; Adam J Schwarz; Christopher H Chatham; David Scott; Jessica A Turner; Jaymin Upadhyay; Alexandre Coimbra; James A Goodman; Richard Baumgartner; Brett A English; John W Apolzan; Preetham Shankapal; Keely R Hawkins
Journal:  Drug Discov Today       Date:  2017-11-15       Impact factor: 7.851

5.  Tyrosine Kinase Inhibitors in the Treatment of Systemic Sclerosis: The Difficulty in Interpreting Proof-of-Concept Studies.

Authors:  Jessica Gordon; Robert Spiera
Journal:  Int J Rheumatol       Date:  2011-10-13

Review 6.  Dose optimisation and scarce resource allocation: two sides of the same coin.

Authors:  Garth Strohbehn; Govind Persad; William F Parker; Srinivas Murthy
Journal:  BMJ Open       Date:  2022-10-12       Impact factor: 3.006
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.