Literature DB >> 10934357

Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1.

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Year:  2000        PMID： 10934357     DOI： 10.1002/(sici)1521-3773(20000515)39:10<1775::aid-anie1775>3.0.co;2-q

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  6 in total

1.  Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue.

Authors:  Shengquan Hu; Rui Wang; Wei Cui; Zaijun Zhang; Shinghung Mak; Daping Xu; Chunglit Choi; Karl Wahkeung Tsim; Paul R Carlier; Mingyuen Lee; Yifan Han
Journal:  J Mol Neurosci       Date:  2014-11-19       Impact factor: 3.444

2.  Investigation of the binding mode of (-)-meptazinol and bis-meptazinol derivatives on acetylcholinesterase using a molecular docking method.

Authors:  Qiong Xie; Yun Tang; Wei Li; Xing-Hai Wang; Zhui-Bai Qiu
Journal:  J Mol Model       Date:  2006-01-11       Impact factor: 1.810

Review 3.  Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.

Authors:  Harry M Greenblatt; Hay Dvir; Israel Silman; Joel L Sussman
Journal:  J Mol Neurosci       Date:  2003       Impact factor: 2.866

4.  Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant.

Authors:  Wen-Cong Yang; Hai-Yan Bao; Ya-Yue Liu; Ying-Ying Nie; Jing-Ming Yang; Peng-Zhi Hong; Yi Zhang
Journal:  Molecules       Date:  2018-09-03       Impact factor: 4.411

Review 5.  Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration.

Authors:  Xiaohe Luo; Marianne Lauwers; Paul G Layer; Chunyi Wen
Journal:  Front Cell Dev Biol       Date:  2021-01-28

6.  A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor.

Authors:  Shengquan Hu; Huihui Hu; Shinghung Mak; Guozhen Cui; Mingyuen Lee; Luchen Shan; Yuqiang Wang; Huangquan Lin; Zaijun Zhang; Yifan Han
Journal:  Front Pharmacol       Date:  2018-02-12       Impact factor: 5.810
  6 in total

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