Literature DB >> 10930264

A facile synthesis of polysubstituted pyrroles.

R K Dieter1, H Yu.   

Abstract

alpha-Aminoalkylcuprates prepared from CuX.2LiCl (X = Cl, CN) and 1 equiv of an alpha-lithiocarbamate undergo conjugate addition reactions to alpha,beta-alkynyl ketones in moderate to good yields, affording E:Z mixtures of alpha,beta-enones. Treatment of the conjugate adducts with PhOH/TMSCl in CH(2)Cl(2) effected carbamate deprotection and cyclization to afford a flexible two-step synthesis of substituted pyrroles.

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Year:  2000        PMID： 10930264     DOI： 10.1021/ol006050q

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Polystyrenesulfonate-catalyzed synthesis of novel pyrroles through Paal-Knorr reaction.

Authors:  Mandira Banik; Bianca Ramirez; Ashwini Reddy; Debasish Bandyopadhyay; Bimal K Banik
Journal:  Org Med Chem Lett       Date:  2012-03-27

2.  Direct Synthesis of Highly Substituted Pyrroles and Dihydropyrroles Using Linear Selective Hydroacylation Reactions.

Authors:  Manjeet K Majhail; Paul M Ylioja; Michael C Willis
Journal:  Chemistry       Date:  2016-04-23       Impact factor: 5.236

3.  Remarkable iodine-catalyzed synthesis of novel pyrrole-bearing N-polyaromatic beta-lactams.

Authors:  Debasish Bandyopadhyay; Gildardo Rivera; Isabel Salinas; Hector Aguilar; Bimal K Banik
Journal:  Molecules       Date:  2010-02-23       Impact factor: 4.411
  3 in total

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