| Literature DB >> 10929066 |
S Butcher1, H Chahel, J M Lord.
Abstract
In the armoury of the immune system developed to combat the various micro-organisms that could invade the host, the neutrophil forms the first line of defence against rapidly dividing bacteria and fungi. However, as humans age they become more susceptible to infection with these microbes and this has been ascribed to a decline in immune status, termed immune senescence. Here we summarize the literature specifically concerning the attenuation of neutrophil function with age and the possible mechanisms underlying their reduced response to infectious agents.Entities:
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Year: 2000 PMID： 10929066 PMCID： PMC2327031 DOI： 10.1046/j.1365-2567.2000.00079.x
Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397