N E Russell1, R E Pachorek. 1. School of Pharmacy, University of the Pacific, Stockton, CA, USA.
Abstract
OBJECTIVE: To evaluate the utility of clindamycin in the treatment of streptococcal and staphylococcal toxic shock syndromes. DATA SOURCES: Biomedical literature was accessed through MEDLINE (1966-December 1999). Key terms included clindamycin, streptococcal toxic shock, and staphylococcal toxic shock. DATA SYNTHESIS: Streptococcal and staphylococcal toxic shock syndromes are associated with a high mortality rate. beta-Lactams have been considered the drug of choice for the treatment of these serious infections, with the occasional use of adjunctive clindamycin, although no clinical evidence has been published to support this latter regimen. An evaluation of the information to propose the usefulness of clindamycin was conducted. CONCLUSIONS: Experimental laboratory evidence suggests utility of the adjunctive use of clindamycin in streptococcal and staphylococcal infections complicated by toxin production. Research using animal models comparing clindamycin plus beta-lactams with beta-lactams alone for the treatment of these infections would be useful.
OBJECTIVE: To evaluate the utility of clindamycin in the treatment of streptococcal and staphylococcal toxic shock syndromes. DATA SOURCES: Biomedical literature was accessed through MEDLINE (1966-December 1999). Key terms included clindamycin, streptococcal toxic shock, and staphylococcal toxic shock. DATA SYNTHESIS: Streptococcal and staphylococcal toxic shock syndromes are associated with a high mortality rate. beta-Lactams have been considered the drug of choice for the treatment of these serious infections, with the occasional use of adjunctive clindamycin, although no clinical evidence has been published to support this latter regimen. An evaluation of the information to propose the usefulness of clindamycin was conducted. CONCLUSIONS: Experimental laboratory evidence suggests utility of the adjunctive use of clindamycin in streptococcal and staphylococcal infections complicated by toxin production. Research using animal models comparing clindamycin plus beta-lactams with beta-lactams alone for the treatment of these infections would be useful.
Authors: R P Dellinger; Mitchell M Levy; Andrew Rhodes; Djillali Annane; Herwig Gerlach; Steven M Opal; Jonathan E Sevransky; Charles L Sprung; Ivor S Douglas; Roman Jaeschke; Tiffany M Osborn; Mark E Nunnally; Sean R Townsend; Konrad Reinhart; Ruth M Kleinpell; Derek C Angus; Clifford S Deutschman; Flavia R Machado; Gordon D Rubenfeld; Steven Webb; Richard J Beale; Jean-Louis Vincent; Rui Moreno Journal: Intensive Care Med Date: 2013-01-30 Impact factor: 17.440