| Literature DB >> 1092585 |
R W McCallum, M M Kline, N Curry, R A Sturdevant.
Abstract
The effects of oral metoclopramide, 10 and 20 mg, bethanechol, 25 mg, and placebo on lower esophageal sphincter pressure (LESP) were studied in 15 men with symptoms of gastroesophageal reflux and basal LESP less than 11 mm Hg. Each drug produced a significant increase in LESP when compared to placebo. Metoclopramide, 20 mg, produced a greater increase than either metoclopramide, 10 mg, or bethanechol, 25 mg. Serum gastrin concentrations were not altered by any of the drugs. Side effects were unremarkable. The LESP increasing effect of metoclopramide might be useful in treatment of gastro-esophageal reflux.Entities:
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Year: 1975 PMID： 1092585
Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682