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Literature DB >> 10925702

The human RNA helicase A (DDX9) gene maps to the prostate cancer susceptibility locus at chromosome band 1q25 and its pseudogene (DDX9P) to 13q22, respectively.

C G Lee¹, T Eki, K Okumura, M Nogami, V da C Soares, Y Murakami, F Hanaoka, J Hurwitz.

Abstract

RNA helicase A is the homolog of the Drosophila maleless protein, an essential factor involved in dosage compensation, and plays a crucial role in early development in mammals. Here, we have mapped the human RNA helicase A (DDX9) gene to the major susceptibility locus for prostate cancer at chromosome band 1q25, and its pseudogene (DDX9P) to the band 13q22 by fluorescence in situ hybridization, somatic cell hybrid analysis, and assignment of YAC clones, respectively.

Entities: Disease Gene Species

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Year: 1999 PMID： 10925702 DOI： 10.1023/b:scam.0000007138.44216.3a

Source DB: PubMed Journal: Somat Cell Mol Genet ISSN： 0740-7750

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Cited

10 in total

1. Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage.

Authors: Marie-Jo Halaby; Benjamin R E Harris; W Keith Miskimins; Margot P Cleary; Da-Qing Yang
Journal: Mol Cell Biol Date: 2015-09-21 Impact factor: 4.272

2. The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR.

Authors: Gatikrushna Singh; Sarah E Fritz; Bradley Seufzer; Kathleen Boris-Lawrie
Journal: J Biol Chem Date: 2020-04-20 Impact factor: 5.157

The human RNA helicase A (DDX9) gene maps to the prostate cancer susceptibility locus at chromosome band 1q25 and its pseudogene (DDX9P) to 13q22, respectively.

1. Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage.

2. The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR.

3. The DNA/RNA helicase DHX9 contributes to the transcriptional program of the androgen receptor in prostate cancer.

4. Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage.

Review 5. Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics.

Review 6. The enigmatic helicase DHX9 and its association with the hallmarks of cancer.

7. Identification of DDX31 as a Potential Oncogene of Invasive Metastasis and Proliferation in PDAC.

Review 8. DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.

Review 9. The biology of DHX9 and its potential as a therapeutic target.

Review 10. The RNA helicase A in malignant transformation.