Literature DB >> 10924790

Evidence of cross-protection within Leptospira interrogans in an experimental model.

C Sonrier1, C Branger, V Michel, N Ruvoën-Clouet, J P Ganière, G André-Fontaine.   

Abstract

Killed whole-cell preparations were used as bacterins against leptospirosis. As this type of protection is considered to be serogroup-specific, several serogroups were added to the usual vaccines, and the most pathogenic serovar was chosen for each group. Different leptospire extracts were evaluated for their protective capacity against acute lethal leptospirosis in gerbils (Meriones unguiculatus). Total extracts induced complete protection against homologous challenges and partial protection against heterologous challenges. LPS fractions protected against homologous but not heterologous challenges, whereas protein extract induced significant protection against both types of challenge. Thus, cross-protection within L. interrogans was related to the protein extract.

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Year:  2000        PMID： 10924790     DOI： 10.1016/s0264-410x(00)00129-8

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  49 in total

Review 1.  Leptospirosis.

Authors:  P N Levett
Journal:  Clin Microbiol Rev       Date:  2001-04       Impact factor: 26.132

2.  Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans.

Authors:  H Guerreiro; J Croda; B Flannery; M Mazel; J Matsunaga; M Galvão Reis; P N Levett; A I Ko; D A Haake
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

3.  Cloning and sequencing of a 21 kDa outer membrane protein gene of Leptospira interrogans serovar Canicola strain Hond Utrecht IV.

Authors:  P S Cheema; S K Srivastava; P Chaudhuri; R Amutha; S Singh; M Sankar; E Thangapandian
Journal:  Vet Res Commun       Date:  2007-01-13       Impact factor: 2.459

4.  Cloning and sequence analysis of the gene encoding LipL32 of Leptospira interrogans serovar Sejroe.

Authors:  R Amutha; P Chaudhury; Amar P Garg; P Vasan; P S Cheema; S K Srivastava
Journal:  Vet Res Commun       Date:  2007-01-13       Impact factor: 2.459

5.  Highly virulent Leptospira borgpetersenii strain characterized in the hamster model.

Authors:  Juliana Alcoforado Diniz; Samuel Rodrigues Félix; Josiane Bonel-Raposo; Amilton Clair Pinto Seixas Neto; Flávia Aleixo Vasconcellos; André Alex Grassmann; Odir Antônio Dellagostin; José Antonio Guimarães Aleixo; Everton Fagonde da Silva
Journal:  Am J Trop Med Hyg       Date:  2011-08       Impact factor: 2.345

6.  Homologous microscopic agglutinating antibodies after natural infection with leptospires - results from a long term follow up of a cohort living in an endemic area.

Authors:  R Vimal Raj; K Vinod Kumar; A P Sugunan; K Natarajaseenivasan; P Vijayachari
Journal:  Pathog Glob Health       Date:  2017-06-23       Impact factor: 2.894

Review 7.  Human leptospirosis vaccines in China.

Authors:  Yinghua Xu; Qiang Ye
Journal:  Hum Vaccin Immunother       Date:  2017-12-19       Impact factor: 3.452

8.  Lack of demonstrable memory T cell responses in humans who have spontaneously recovered from leptospirosis in the Peruvian Amazon.

Authors:  Iskra Tuero; Joseph M Vinetz; Gary R Klimpel
Journal:  J Infect Dis       Date:  2010-02-01       Impact factor: 5.226

9.  Isolation and characterization of new Leptospira genotypes from patients in Mayotte (Indian Ocean).

Authors:  Pascale Bourhy; Louis Collet; Sabine Clément; Michel Huerre; Patrick Ave; Claude Giry; François Pettinelli; Mathieu Picardeau
Journal:  PLoS Negl Trop Dis       Date:  2010-06-22

10.  A conserved region of leptospiral immunoglobulin-like A and B proteins as a DNA vaccine elicits a prophylactic immune response against leptospirosis.

Authors:  Karine M Forster; Daiane D Hartwig; Fabiana K Seixas; Kátia L Bacelo; Marta Amaral; Cláudia P Hartleben; Odir A Dellagostin
Journal:  Clin Vaccine Immunol       Date:  2013-03-13
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