Literature DB >> 10924708

Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain.

I Brailov1, M Bancila, M J Brisorgueil, M C Miquel, M Hamon, D Vergé.   

Abstract

5-HT(6) receptor-like immunoreactivity has been previously found in association with both neuronal dendrites and cilia in the striatum, nucleus accumbens, olfactory tubercle and islands of Calleja of the rat brain. Using immunogold pre-embedding immunocytochemical techniques to investigate the subcellular localization of 5-HT(6) receptor-like immunoreactivity in cilia, we showed that immunogold particles were associated with their plasma membrane, and not with microtubules. This membrane localization is consistent with a possible physiological role, which is still unknown, of these receptors.

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Year:  2000        PMID： 10924708     DOI： 10.1016/s0006-8993(00)02519-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  92 in total

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4.  5-HT6 receptor blockade regulates primary cilia morphology in striatal neurons.

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5.  NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base.

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Review 8.  Cilia and developmental signaling.

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9.  Cilia and Hedgehog responsiveness in the mouse.

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Review 10.  The primary cilium as a complex signaling center.

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