Literature DB >> 10924693

Does endogenous 5-HT mediate spontaneous rhythmic activity in chemoreceptor clusters of rat carotid body?

M Zhang1, C A Nurse.   

Abstract

Spontaneous voltage fluctuations often occurred during perforated-patch recordings from clustered rat carotid body (CB) chemoreceptors in vitro. This activity sometimes appeared as rhythmic-like spikes, when cluster size exceeded approximately 20 cells. Spike discharge could be augmented or induced by hypoxia or 5-HT (2-10 microM) application, and inhibited by the 5-HT receptor blocker, ketanserin (50-100 microM). Thus, endogenous 5-HT may contribute to spontaneous firing within CB receptor clusters via autocrine/paracrine mechanisms.

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Year:  2000        PMID： 10924693     DOI： 10.1016/s0006-8993(00)02499-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

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5.  Presynaptic modulation of rat arterial chemoreceptor function by 5-HT: role of K+ channel inhibition via protein kinase C.

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Review 8.  TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing.

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Authors:  M Pozdzik; D Zajac; I Zasada; Z Czarnocki; Z Matysiak; A Mazzatenta; M Pokorski
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