Literature DB >> 10924192

Hepatoprotective diastereomeric lignans from Saururus chinensis herbs.

S H Sung1, Y C Kim.   

Abstract

Two new diastereomeric sauchinones (2, 3), along with the known sauchinone (1), a phenylpropanoid (sarisan), and two known lignans (galbacin and saucernetin), were isolated from the n-hexane fraction of Saururus chinensis using reversed-phase HPLC. The stereostructures of the lignans, sauchinone A (2) and 1'-epi-sauchinone (3), were established by analysis of spectroscopic data. Incubation of cultured rat hepatocytes intentionally injured by CCl(4) with each of the compounds 1, 2, and 3 significantly reduced the levels of glutamic pyruvic transaminase released by the damaged hepatocytes.

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Year:  2000        PMID： 10924192     DOI： 10.1021/np990499e

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

1.  Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.

Authors:  Hee Yeon Kay; Young Woo Kim; Da Hye Ryu; Sang Hyun Sung; Se Jin Hwang; Sang Geon Kim
Journal:  Br J Pharmacol       Date:  2011-08       Impact factor: 8.739

2.  Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation.

Authors:  Ae Kyung Lee; Sang Hyun Sung; Young Choong Kim; Sang Geon Kim
Journal:  Br J Pharmacol       Date:  2003-05       Impact factor: 8.739

Review 3.  Oxidative dehydrogenative couplings of alkenyl phenols.

Authors:  William C Neuhaus; Adriana L Jemison; Marisa C Kozlowski
Journal:  Org Biomol Chem       Date:  2021-10-06       Impact factor: 3.890

4.  Attenuation of inflammatory-mediated neurotoxicity by Saururus chinensis extract in LPS-induced BV-2 microglia cells via regulation of NF-κB signaling and anti-oxidant properties.

Authors:  Byung-Wook Kim; Sushruta Koppula; Shin-Young Park; Jin-Woo Hwang; Pyo-Jam Park; Ji-Hong Lim; Dong-Kug Choi
Journal:  BMC Complement Altern Med       Date:  2014-12-16       Impact factor: 3.659

5.  Evaluation of antioxidant and anticancer activities of chemical constituents of the Saururus chinensis root extracts.

Authors:  Abdullah Alaklabi; Ibrahim A Arif; Anis Ahamed; Radhakrishnan Surendra Kumar; Akbar Idhayadhulla
Journal:  Saudi J Biol Sci       Date:  2017-01-03       Impact factor: 4.219

6.  Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity.

Authors:  Byoung Hoon You; Eun Chae Gong; Young Hee Choi
Journal:  Molecules       Date:  2018-02-09       Impact factor: 4.411

7.  Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway.

Authors:  Jae-Hyoung Song; Jae-Hee Ahn; Seong-Ryeol Kim; Sungchan Cho; Eun-Hye Hong; Bo-Eun Kwon; Dong-Eun Kim; Miri Choi; Hwa-Jung Choi; Younggil Cha; Sun-Young Chang; Hyun-Jeong Ko
Journal:  Sci Rep       Date:  2019-06-28       Impact factor: 4.379

8.  Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathways.

Authors:  Seok Jai Kim; Cheol Won Jeong; Hong Beom Bae; Sang Hyun Kwak; Jong-Keun Son; Chang-Seob Seo; Hyun-Jung Lee; JongUn Lee; Kyung Yeon Yoo
Journal:  J Korean Med Sci       Date:  2012-04-25       Impact factor: 2.153

9.  KBH-1, an herbal composition, improves hepatic steatosis and leptin resistance in high-fat diet-induced obese rats.

Authors:  Ji-Hye Lee; Jung-Jin Lee; Won-Kyung Cho; Nam-Hui Yim; Hyun-Kyu Kim; Bora Yun; Jin Yeul Ma
Journal:  BMC Complement Altern Med       Date:  2016-09-13       Impact factor: 3.659

10.  Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network.

Authors:  Hee-Sung Chae; Byoung Hoon You; Dong-Yeop Kim; Hankyu Lee; Hyuk Wan Ko; Hyun-Jeong Ko; Young Hee Choi; Sun Shim Choi; Young-Won Chin
Journal:  Sci Rep       Date:  2018-04-30       Impact factor: 4.379
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