Literature DB >> 10924096

Isolation and characterization of neural stem cells from the adult human olfactory bulb.

S F Pagano1, F Impagnatiello, M Girelli, L Cova, E Grioni, M Onofri, M Cavallaro, S Etteri, F Vitello, S Giombini, C L Solero, E A Parati.   

Abstract

We have recently isolated stem cells deriving from the olfactory bulbs of adult patients undergoing particularly invasive neurosurgery. After improving our experimental conditions, we have now obtained neural stem cells according to clonal analysis. The cells can be expanded, established in continuous cell lines and differentiated into the three classical neuronal phenotypes (neurons, astrocytes, and oligodendrocytes). Also, after exposition to leukemia inhibitory factor, we are able to improve the number of neurons, an ideal biological source for transplantation in various neurodegenerative disorders.

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Year:  2000        PMID： 10924096     DOI： 10.1634/stemcells.18-4-295

Source DB:  PubMed          Journal:  Stem Cells        ISSN： 1066-5099            Impact factor:   6.277


  58 in total

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2.  Differential centrifugation in culture and differentiation of rat neural stem cells.

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Review 5.  Brain stem cells as the cell of origin in glioma.

Authors:  Aram S Modrek; N Sumru Bayin; Dimitris G Placantonakis
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Review 6.  Neural plasticity in developing and adult olfactory pathways - focus on the human olfactory bulb.

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7.  Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia.

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8.  Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation.

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Review 9.  Cerebral cortex: a target and source of insulin?

Authors:  Éva A Csajbók; Gábor Tamás
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10.  Convergence of cells from the progenitor fraction of adult olfactory bulb tissue to remyelinating glia in demyelinating spinal cord lesions.

Authors:  Eleni A Markakis; Masanori Sasaki; Karen L Lankford; Jeffery D Kocsis
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