Literature DB >> 10923231

Tuberculous meningitis in children: problem to be addressed effectively with thorough contact tracing.

R Walia1, W Hoskyns.   

Abstract

UNLABELLED: Worldwide, tuberculosis is the most common cause of death from a single infectious agent in children. There has been an increase in its incidence in Europe in recent years. Early diagnosis of tuberculous meningitis in children is extremely difficult because of its nonspecific early presentation and it is universally fatal if not recognised and treated. Young children are at increased risk of acquiring tuberculosis and it is more likely to be disseminated in neonates. In summarising the cases of three children with tuberculous meningitis admitted to our centre, we highlight the importance of diagnosis and contact tracing of the source case.
CONCLUSION: Diagnosis of tuberculous meningitis requires a high index of suspicion, thorough contact tracing, and appropriate investigations with early treatment as the key to reducing morbidity and mortality.

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Year:  2000        PMID: 10923231     DOI: 10.1007/s004310051327

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN: 0340-6199            Impact factor:   3.183


  3 in total

Review 1.  Paediatric tuberculosis.

Authors:  W Hoskyns
Journal:  Postgrad Med J       Date:  2003-05       Impact factor: 2.401

2.  Tuberculous meningitis: a disease of fatal outcome in children.

Authors:  Ibrahim M Khan; Samreen Khan; Ulrich Laaser
Journal:  Eur J Pediatr       Date:  2003-02-21       Impact factor: 3.183

3.  Use of IMiD3, a thalidomide analog, as an adjunct to therapy for experimental tuberculous meningitis.

Authors:  Liana Tsenova; Bande Mangaliso; George Muller; Yong Chen; Victoria H Freedman; David Stirling; Gilla Kaplan
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

  3 in total

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