Literature DB >> 10922486

The gene for hepatocyte nuclear factor (HNF)-4alpha is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver.

S Oyadomari1, F Matsuno, S Chowdhury, T Kimura, K Iwase, E Araki, M Shichiri, M Mori, M Takiguchi.   

Abstract

The gene for a transcription factor hepatocyte nuclear factor-4alpha (HNF-4alpha) is responsible for maturity-onset diabetes of the young, type 1. We examined hormonal regulation of the HNF-4alpha gene in the liver. Stimulation of primary-cultured rat hepatocytes with dexamethasone or glucagon led to induction of HNF-4alpha mRNA, being antagonized by insulin. In the liver of streptozotocin-induced diabetic rat, mRNA and protein levels for HNF-4alpha were elevated, and were normalized by insulin treatment. Therefore, HNF-4alpha in the liver is likely to be involved in the regulation of glucose metabolism in response to these hormones.

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Year:  2000        PMID： 10922486     DOI： 10.1016/s0014-5793(00)01840-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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Authors:  S Oyadomari; K Takeda; M Takiguchi; T Gotoh; M Matsumoto; I Wada; S Akira; E Araki; M Mori
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

2.  An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors.

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Journal:  PLoS One       Date:  2012-08-08       Impact factor: 3.240

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  8 in total

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