Pharmacologic and clinical control of antiarrhythmic drugs.

Knowledge of pharmacokinetics and pharmacodynamics is a powerful tool for controlling cardiac arrhythmias with drugs even though antiarrhythmic drugs are potentially quite toxic. If the diagnosis and drug selection are correct at the outset of therapy, the clinician can use his knowledge of pharmacokinetics to achieve arrhythmia control with a minimum of personal effort and risk to his patient.