Y Kuang1, Z Zhang, X Zhang. 1. Surgery Department, First Affiliated Hospital, Suzhou Medical College.
Abstract
OBJECTIVE: To study interleukin-6(IL-6) and its receptors in human breast cancer. METHODS: Using ELISA method and ABC immunohistochemistry, IL-6 and its receptors were examined in 45 cases of breast cancer, 10 cases of benign breast diseases and 17 cases of healthy women. RESULTS: High levels of serum IL-6 and its soluble receptors were frequently observed in breast cancer patients. The levels correlated with the stage and axillary lymph node involvement. The positive staining of IL-6, IL-6R alpha, gp130 were 68.9% in neoplasm tissue. CONCLUSION: IL-6 and its soluble receptors may be important paramenters reflecting the biological behaviour and prognosis of breast cancer.
OBJECTIVE: To study interleukin-6(IL-6) and its receptors in humanbreast cancer. METHODS: Using ELISA method and ABC immunohistochemistry, IL-6 and its receptors were examined in 45 cases of breast cancer, 10 cases of benign breast diseases and 17 cases of healthy women. RESULTS: High levels of serum IL-6 and its soluble receptors were frequently observed in breast cancerpatients. The levels correlated with the stage and axillary lymph node involvement. The positive staining of IL-6, IL-6R alpha, gp130 were 68.9% in neoplasm tissue. CONCLUSION:IL-6 and its soluble receptors may be important paramenters reflecting the biological behaviour and prognosis of breast cancer.
Authors: Janina V Pearce; Jared S Farrar; Joseph C Lownik; Bin Ni; Shanshan Chen; Tiffany W Kan; Francesco S Celi Journal: Biochem Biophys Rep Date: 2019-03-20