M E Rode1, M A Morgan, E Ruchelli, I Forouzan. 1. Division of Maternal-Fetal Medicine, University of Pennsylvania Health System, Philadelphia 19104, USA. mrode@mail.obgyn.upenn.edu
Abstract
BACKGROUND: Reduction amniocentesis is used in cases of severe polyhydramnios to decrease maternal discomfort and the risk of preterm labor. In a MEDLINE search (1966 to present, English language, keywords: amniocentesis, chorioamnionitis), no report of Candida chorioamnionitis after serial reduction amniocentesis exists. CASE: A 29-year-old primigravida with a history of four therapeutic amniocenteses for idiopathic polyhydramnios developed preterm labor at 30 and 5/7 weeks' gestation, rupture of membranes, and Candida albicans chorioamnionitis. Despite aggressive therapy with amphotericin B, the neonate succumbed to overwhelming systemic candidiasis. CONCLUSION: Serial amniocentesis may place patients at elevated risk for Candida chorioamnionitis and subsequent preterm delivery. Clinicians should consider early diagnostic amniocentesis in patients in preterm labor with a history of prior amniocentesis, and the routine Gram stain and culture of amniotic fluid.
BACKGROUND: Reduction amniocentesis is used in cases of severe polyhydramnios to decrease maternal discomfort and the risk of preterm labor. In a MEDLINE search (1966 to present, English language, keywords: amniocentesis, chorioamnionitis), no report of Candida chorioamnionitis after serial reduction amniocentesis exists. CASE: A 29-year-old primigravida with a history of four therapeutic amniocenteses for idiopathic polyhydramnios developed preterm labor at 30 and 5/7 weeks' gestation, rupture of membranes, and Candida albicans chorioamnionitis. Despite aggressive therapy with amphotericin B, the neonate succumbed to overwhelming systemic candidiasis. CONCLUSION: Serial amniocentesis may place patients at elevated risk for Candida chorioamnionitis and subsequent preterm delivery. Clinicians should consider early diagnostic amniocentesis in patients in preterm labor with a history of prior amniocentesis, and the routine Gram stain and culture of amniotic fluid.
Authors: A S Ibara; P Marcorelles; M T Le Martelot; N Touffet; E Moalic; G Hery-Arnaud; J D Giroux; A M Le Flohic Journal: Eur J Clin Microbiol Infect Dis Date: 2003-12-02 Impact factor: 3.267
Authors: Matthew S Payne; Matthew W Kemp; Suhas G Kallapur; Paranthaman Senthamarai Kannan; Masatoshi Saito; Yuichiro Miura; John P Newnham; Sarah Stock; Demelza J Ireland; Boris W Kramer; Alan H Jobe Journal: Pediatr Res Date: 2014-03-14 Impact factor: 3.756