Literature DB >> 10919084

Novel approaches in the rational design of antifungal agents of low toxicity.

E Borowski1.   

Abstract

This paper presents an overview of studies on novel strategies for the rational design of antifungal agents of low toxicity and overcoming the multidrug resistance (MDR) of fungi. This goal was achieved both due to the introduction of a novel target, glucosamine-6-phosphate synthase, as well as to the recognition of molecular basis of selectivity of action of amphotericin B derivatives.

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Year:  2000        PMID： 10919084     DOI： 10.1016/s0014-827x(00)00024-0

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  15 in total

1.  Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc.

Authors:  Aleksandra Miszkiel; Marek Wojciechowski; Sławomir Milewski
Journal:  J Mol Model       Date:  2011-03-02       Impact factor: 1.810

2.  Novel Nystatin A₁ derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis.

Authors:  Joanna Boros-Majewska; Natalia Salewska; Edward Borowski; Sławomir Milewski; Sladjana Malic; Xiao-Qing Wei; Anthony J Hayes; Melanie J Wilson; David W Williams
Journal:  Med Microbiol Immunol       Date:  2014-06-13       Impact factor: 3.402

3.  Functional domains and interdomain communication in Candida albicans glucosamine-6-phosphate synthase.

Authors:  Jarosław Olchowy; Iwona Gabriel; Sławomir Milewski
Journal:  Biochem J       Date:  2007-05-15       Impact factor: 3.857

4.  Glucosamine: fructose-6-phosphate amidotransferase in the white shrimp Litopenaeus vannamei: characterization and regulation under alkaline and cadmium stress.

Authors:  Y Liu; D X Cai; L Wang; J Z Li; W N Wang
Journal:  Ecotoxicology       Date:  2015-05-09       Impact factor: 2.823

5.  Structure-antifungal activity relationships of polyene antibiotics of the amphotericin B group.

Authors:  Anna N Tevyashova; Evgenia N Olsufyeva; Svetlana E Solovieva; Svetlana S Printsevskaya; Marina I Reznikova; Aleksei S Trenin; Olga A Galatenko; Ivan D Treshalin; Eleonora R Pereverzeva; Elena P Mirchink; Elena B Isakova; Sergey B Zotchev; Maria N Preobrazhenskaya
Journal:  Antimicrob Agents Chemother       Date:  2013-05-28       Impact factor: 5.191

6.  The effect of sterols on amphotericin B self-aggregation in a lipid bilayer as revealed by free energy simulations.

Authors:  Anna Neumann; Maciej Baginski; Szymon Winczewski; Jacek Czub
Journal:  Biophys J       Date:  2013-04-02       Impact factor: 4.033

7.  An anti-beta-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo.

Authors:  Anna Rachini; Donatella Pietrella; Patrizia Lupo; Antonella Torosantucci; Paola Chiani; Carla Bromuro; Carla Proietti; Francesco Bistoni; Antonio Cassone; Anna Vecchiarelli
Journal:  Infect Immun       Date:  2007-07-02       Impact factor: 3.441

8.  In Silico Design and Selection of Anti-fungal AmB-polyene-analog Lead Molecules by Virtual Screening Method.

Authors:  Marziyeh Ferdosiyan; Soroush Sardari
Journal:  Avicenna J Med Biotechnol       Date:  2010-07

9.  Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail.

Authors:  Joanna Zielińska; Miłosz Wieczór; Tomasz Bączek; Marcin Gruszecki; Jacek Czub
Journal:  Sci Rep       Date:  2016-01-08       Impact factor: 4.379

10.  Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether.

Authors:  Mohamed Reda Aouad; Mariem Mohammed Mayaba; Arshi Naqvi; Sanaa K Bardaweel; Fawzia Faleh Al-Blewi; Mouslim Messali; Nadjet Rezki
Journal:  Chem Cent J       Date:  2017-11-21       Impact factor: 4.215
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