Literature DB >> 10918949

Synthesis and antisecretory activity of 6-substituted 5-cyanomethylimidazo[2,1-b]thiazoles and 2,6-dimethyl-5-hydroxymethylimidazo[2,1-b][1,3,4]thiadiazole.

A Andreani1, A Leoni, A Locatelli, R Morigi, M Rambaldi, W A Simon, J Senn-Bilfinger.   

Abstract

The synthesis of imidazo[2,1-b]thiazole and imidazo[2,1-b][1,3,4]thiadiazole derivatives, related to known antiulcer agents, is reported. 5-Cyanomethyl-6-methylimidazo[2,1-b]thiazole showed significant antisecretory activity in the isolated rabbit gastric glands assay.

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Year:  2000        PMID： 10918949     DOI： 10.1055/s-0031-1300247

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  2 in total

1.  Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

Authors:  Aldo Andreani; Massimiliano Granaiola; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Lucilla Varoli; Natalia Calonghi; Concettina Cappadone; Giovanna Farruggia; Claudio Stefanelli; Lanfranco Masotti; Tam L Nguyen; Ernest Hamel; Robert H Shoemaker
Journal:  J Med Chem       Date:  2012-02-15       Impact factor: 7.446

2.  Synthesis and antibacterial activities of novel imidazo[2,1-b]-1,3,4-thiadiazoles.

Authors:  Kamal F M Atta; Omaima O M Farahat; Alaa Z A Ahmed; Mohamed G Marei
Journal:  Molecules       Date:  2011-06-28       Impact factor: 4.411
  2 in total

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