Literature DB >> 109189

Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.

T J Slaga, G L Gleason, J DiGiovanni, K B Sukumaran, R G Harvey.   

Abstract

The abilities of the racemic trans-3,4-, 5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7,12-dimethylbenz(a)anthracene trans-5,6- and 8,9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene is a proximal carcinogen and that the "bay region" diol-epoxide may be the ultimate carcinogenic form of DMBA.

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Year:  1979        PMID： 109189

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  10 in total

Review 1.  The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.

Authors:  Ercole Cavalieri; Eleanor Rogan
Journal:  Mol Aspects Med       Date:  2013-08-30

Review 2.  Metabolism and activation of chemical carcinogens.

Authors:  E K Weisburger
Journal:  Mol Cell Biochem       Date:  1980-09-15       Impact factor: 3.396

3.  Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.

Authors:  Badri G Modi; Jason Neustadter; Elisa Binda; Julia Lewis; Renata B Filler; Scott J Roberts; Bernice Y Kwong; Swapna Reddy; John D Overton; Anjela Galan; Robert Tigelaar; Lining Cai; Peter Fu; Mark Shlomchik; Daniel H Kaplan; Adrian Hayday; Michael Girardi
Journal:  Science       Date:  2012-01-06       Impact factor: 47.728

4.  Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.

Authors:  D Chakravarti; J C Pelling; E L Cavalieri; E G Rogan
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-24       Impact factor: 11.205

5.  Polycyclic aromatic hydrocarbons and possible metabolites: convertogenic activity in yeast and tumor initiating activity in mouse skin.

Authors:  D Siebert; H Marquardt; H Friesel; E Hecker
Journal:  J Cancer Res Clin Oncol       Date:  1981       Impact factor: 4.553

6.  Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.

Authors:  Keith Syson Chan; Shigetoshi Sano; Kaoru Kiguchi; Joanne Anders; Nobuyasu Komazawa; Junji Takeda; John DiGiovanni
Journal:  J Clin Invest       Date:  2004-09       Impact factor: 14.808

Review 7.  Differentiation of the mammary gland and susceptibility to carcinogenesis.

Authors:  J Russo; L K Tay; I H Russo
Journal:  Breast Cancer Res Treat       Date:  1982       Impact factor: 4.872

8.  Metabolism of 7,12-dimethylbenzanthracene (DMBA) by mouse skin keratinocytes, fibroblasts, and carcinoma cells in culture.

Authors:  G Irmscher; N E Fusenig
Journal:  Arch Toxicol       Date:  1980-03       Impact factor: 5.153

Review 9.  SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice.

Authors:  T J Slaga
Journal:  Environ Health Perspect       Date:  1986-09       Impact factor: 9.031

10.  Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.

Authors:  Rafal Zur; Laura Garcia-Ibanez; Angel Nunez-Buiza; Noelia Aparicio; Georgios Liappas; Alejandra Escós; Ana Risco; Angustias Page; Cristina Saiz-Ladera; Dayanira Alsina-Beauchamp; José Montans; Jesús M Paramio; Ana Cuenda
Journal:  Oncotarget       Date:  2015-05-30
  10 in total

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