Retinal stem cells in vertebrates.

In fish and amphibia, retinal stem cells located in the periphery of the retina, the ciliary marginal zone (CMZ), produce new neurons in the retina throughout life. In these species, the retina grows to keep pace with the enlarging body. When birds or mammals reach adult proportions, however, their retinas stop growing so there appears to be no need for such a proliferative area with stem cells. It is a surprise, therefore, that recent data suggest that a region similar to the CMZ of fish and amphibia exists in the postnatal chick and the adult mouse. Copyright 2000 John Wiley & Sons, Inc.