B S Sorg1, K M McNally, A J Welch. 1. Biomedical Engineering Laser Laboratory, University of Texas at Austin, Austin, Texas 78712, USA. sorg@mail.utexas.edu
Abstract
BACKGROUND AND OBJECTIVE: The purpose of this study was to determine whether solid material reinforcement of a liquid albumin solder coagulum could improve the cohesive strength of the solder and, thus, the ultimate breaking strength of the incision repair in vitro. STUDY DESIGN/ MATERIALS AND METHODS: A 50%(w/v) bovine serum albumin solder with 0.5 or 2.5 mg/ml indocyanine green (ICG) dye was used to repair an incision in bovine aorta. The solder was coagulated with an 806-nm continuous wave diode laser. A 50-micrometer-thick poly(DL-lactic-co-glycolic acid) film was used to reinforce the solder (the controls had solder but no reinforcement). Acute breaking strengths were measured, and the data were analyzed by Student's t-test. RESULTS: Observations of the failure modes indicate cohesive strength reinforcement of the test specimens vs. the controls. The 2.5 mg/ml ICG reinforced solder was stronger than the controls without reinforcement (P < 0.05) for all laser powers tested. There was no difference between the test specimens and the controls with 0.5 mg/ml ICG solder for low laser powers, but at higher laser powers, the reinforced solder was stronger than the controls (P < 0.05). CONCLUSION: Reinforcement of liquid albumin solders in laser-assisted incision repair seems to have advantages in terms of acute breaking strength over conventional methods that do not reinforce the cohesive strength of the solder. Copyright 2000 Wiley-Liss, Inc.
BACKGROUND AND OBJECTIVE: The purpose of this study was to determine whether solid material reinforcement of a liquid albumin solder coagulum could improve the cohesive strength of the solder and, thus, the ultimate breaking strength of the incision repair in vitro. STUDY DESIGN/ MATERIALS AND METHODS: A 50%(w/v) bovine serum albumin solder with 0.5 or 2.5 mg/ml indocyanine green (ICG) dye was used to repair an incision in bovine aorta. The solder was coagulated with an 806-nm continuous wave diode laser. A 50-micrometer-thick poly(DL-lactic-co-glycolic acid) film was used to reinforce the solder (the controls had solder but no reinforcement). Acute breaking strengths were measured, and the data were analyzed by Student's t-test. RESULTS: Observations of the failure modes indicate cohesive strength reinforcement of the test specimens vs. the controls. The 2.5 mg/ml ICG reinforced solder was stronger than the controls without reinforcement (P < 0.05) for all laser powers tested. There was no difference between the test specimens and the controls with 0.5 mg/ml ICG solder for low laser powers, but at higher laser powers, the reinforced solder was stronger than the controls (P < 0.05). CONCLUSION: Reinforcement of liquid albumin solders in laser-assisted incision repair seems to have advantages in terms of acute breaking strength over conventional methods that do not reinforce the cohesive strength of the solder. Copyright 2000 Wiley-Liss, Inc.
Authors: Dara R Pabittei; Michal Heger; Marc Simonet; Sjoerd van Tuijl; Allard C van der Wal; Ed van Bavel; Ron Balm; Bas A J M de Mol Journal: J Clin Transl Res Date: 2015-06-21
Authors: Dara R Pabittei; Michal Heger; Johan F Beek; Sjoerd van Tuijl; Marc Simonet; Allard C van der Wal; Bas A de Mol; Ron Balm Journal: Ann Biomed Eng Date: 2010-09-11 Impact factor: 3.934