BACKGROUND: Ductal involvement (DI) is often observed in superficial squamous cell carcinoma of the esophagus (SSCCE), defined as carcinoma with invasion limited to the submucosa. The purpose of this study was to clarify the clinicopathologic significance of DI in SSCCE. METHODS: Two hundred one surgically resected lesions from 140 patients with SSCCE were examined histopathologically. Clinicopathologic factors, such as macroscopic type, tumor location, maximum tumor size, depth of invasion, lymphatic and blood vessel permeation, lymph node metastasis, and prognosis, were examined to investigate the association between these factors and the presence of DI. RESULTS: Of the 201 SSCCE lesions, 43 (21.3%) had 152 DIs (1-32 DIs per lesion). The DI always remained in situ, and there were no tumors showing submucosal invasion through the DI. As for the relation between clinicopathologic factors and the presence of DI, multivariate analysis showed only maximum tumor size to correlate with the presence of DI (P < 0.0001). There were no significant differences between DI negative and DI positive lesions in tumor location, macroscopic type, lymphatic and blood vessel permeation, lymph node metastasis, or prognosis. In 83 mucosal carcinomas, including in situ carcinomas or carcinomas that invaded no deeper than the lamina muscularis mucosa, no lymph node metastasis was found, and the 5-year survival rate was 100% (unaffected by the presence of DI). Among these 83 lesions, DI was found in 11 (13.8%), of which 6 (7.2%) had DI extending to the submucosal layer. CONCLUSIONS: These results indicate that DI as a pathway of tumor spread to the deeper layer is of little significance in squamous cell carcinoma of the esophagus, and that mucosal carcinomas with DI that extends to the submucosa should not be classified as submucosal carcinoma. Copyright 2000 American Cancer Society.
BACKGROUND: Ductal involvement (DI) is often observed in superficial squamous cell carcinoma of the esophagus (SSCCE), defined as carcinoma with invasion limited to the submucosa. The purpose of this study was to clarify the clinicopathologic significance of DI in SSCCE. METHODS: Two hundred one surgically resected lesions from 140 patients with SSCCE were examined histopathologically. Clinicopathologic factors, such as macroscopic type, tumor location, maximum tumor size, depth of invasion, lymphatic and blood vessel permeation, lymph node metastasis, and prognosis, were examined to investigate the association between these factors and the presence of DI. RESULTS: Of the 201 SSCCE lesions, 43 (21.3%) had 152 DIs (1-32 DIs per lesion). The DI always remained in situ, and there were no tumors showing submucosal invasion through the DI. As for the relation between clinicopathologic factors and the presence of DI, multivariate analysis showed only maximum tumor size to correlate with the presence of DI (P < 0.0001). There were no significant differences between DI negative and DI positive lesions in tumor location, macroscopic type, lymphatic and blood vessel permeation, lymph node metastasis, or prognosis. In 83 mucosal carcinomas, including in situ carcinomas or carcinomas that invaded no deeper than the lamina muscularis mucosa, no lymph node metastasis was found, and the 5-year survival rate was 100% (unaffected by the presence of DI). Among these 83 lesions, DI was found in 11 (13.8%), of which 6 (7.2%) had DI extending to the submucosal layer. CONCLUSIONS: These results indicate that DI as a pathway of tumor spread to the deeper layer is of little significance in squamous cell carcinoma of the esophagus, and that mucosal carcinomas with DI that extends to the submucosa should not be classified as submucosal carcinoma. Copyright 2000 American Cancer Society.
Authors: Marnix Jansen; Dirk W Schölvinck; Ryoji Kushima; Shigeki Sekine; Bas L A M Weusten; Guiqi Q Wang; David E Fleischer; Shigetaka Yoshinaga; Sanford M Dawsey; Sybren L Meijer; Jacques J G H M Bergman; Ichiro Oda Journal: Gastrointest Endosc Date: 2014-12 Impact factor: 9.427
Authors: Yan Ke; Sanne N van Munster; Liyan Xue; Shun He; Yueming Zhang; Lizhou Dou; Yong Liu; Xudong Liu; Yumeng Liu; Wei Li; Ning Lv; Sanford M Dawsey; Bas L A M Weusten; Jacques J G H M Bergman; Guiqi Wang Journal: Gastrointest Endosc Date: 2019-03-25 Impact factor: 9.427
Authors: Xinying Yu; Sanne N van Munster; Yueming Zhang; Liyan Xue; David E Fleischer; Bas L A M Weusten; Ning Lu; Sanford S M Dawsey; Jacques J G H M Bergman; Guiqi Wang Journal: Gastrointest Endosc Date: 2018-10-26 Impact factor: 9.427
Authors: Rehan J Haidry; Mohammed A Butt; Jason Dunn; Matthew Banks; Abhinav Gupta; Howard Smart; Pradeep Bhandari; Lesley Ann Smith; Robert Willert; Grant Fullarton; Morris John; Massimo Di Pietro; Ian Penman; Marco Novelli; Laurence B Lovat Journal: World J Gastroenterol Date: 2013-09-28 Impact factor: 5.742