Literature DB >> 10917842

Molecular biology. Creation's seventh day.

R F Service.   

Abstract

Scientists at the Scripps Research Institute are attempting to find out what life would look like if DNA contained more than four nucleotide bases and proteins more than 20 amino acids. By reengineering DNA, RNA, and the proteins that interact with them, they hope to create synthetic organisms with a chemical makeup fundamentally different from all life that has existed on Earth for the last 3.8 billion years. If they succeed, their biochemical reengineering could have a profound effect on everything from basic molecular biology to industrial chemistry.

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Year:  2000        PMID: 10917842     DOI: 10.1126/science.289.5477.232

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  4 in total

1.  Decoding of tandem quadruplets by adjacent tRNAs with eight-base anticodon loops.

Authors:  B Moore; C C Nelson; B C Persson; R F Gesteland; J F Atkins
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

2.  PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1.

Authors:  A Michael Sismour; Stefan Lutz; Jeong-Ho Park; Michael J Lutz; Paul L Boyer; Stephen H Hughes; Steven A Benner
Journal:  Nucleic Acids Res       Date:  2004-02-02       Impact factor: 16.971

3.  Highly specific unnatural base pair systems as a third base pair for PCR amplification.

Authors:  Rie Yamashige; Michiko Kimoto; Yusuke Takezawa; Akira Sato; Tsuneo Mitsui; Shigeyuki Yokoyama; Ichiro Hirao
Journal:  Nucleic Acids Res       Date:  2011-11-24       Impact factor: 16.971

Review 4.  Unnatural base pair systems toward the expansion of the genetic alphabet in the central dogma.

Authors:  Ichiro Hirao; Michiko Kimoto
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2012       Impact factor: 3.493

  4 in total

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