Exercise hyperpnea: where do we go from here?

Pulmonary ventilation (VE) increases during exercise to meet the demands of increased oxygen consumption (VO2) and CO2 production. Despite numerous studies over the past century, the mechanism mediating exercise hyperpnea remains controversial. Progress has been limited primarily by the incomplete understanding of the complex basic ventilatory control system and by the difficulty of significantly manipulating a single potential pathway while still performing physiologic exercise. Where do we go from here to further study the exercise hyperpnea?