Literature DB >> 10915629

Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.

S Kaneko1, T Hikida, D Watanabe, H Ichinose, T Nagatsu, R J Kreitman, I Pastan, S Nakanishi.   

Abstract

The physiological role of striatal cholinergic interneurons was investigated with immunotoxin-mediated cell targeting (IMCT). Unilateral cholinergic cell ablation caused an acute abnormal turning behavior. These mice showed gradual recovery but displayed abnormal turning by both excess stimulation and inhibition of dopamine actions. In the acute phase, basal ganglia function was shifted to a hyperactive state by stimulation and suppression of striatonigral and striatopallidal neurons, respectively. D1 and D2 dopamine receptors were then down-regulated, relieving dopamine-predominant synaptic perturbation but leaving a defect in controlling dopamine responses. The acetylcholine-dopamine interaction is concertedly and adaptively regulated for basal ganglia synaptic integration.

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Year:  2000        PMID： 10915629     DOI： 10.1126/science.289.5479.633

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  49 in total

1.  Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.

Authors:  M Yamada; K G Lamping; A Duttaroy; W Zhang; Y Cui; F P Bymaster; D L McKinzie; C C Felder; C X Deng; F M Faraci; J Wess
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-13       Impact factor: 11.205

2.  Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens.

Authors:  T Hikida; S Kaneko; T Isobe; Y Kitabatake; D Watanabe; I Pastan; S Nakanishi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

3.  Voltage-dependent membrane potential oscillations of rat striatal fast-spiking interneurons.

Authors:  Enrico Bracci; Diego Centonze; Giorgio Bernardi; Paolo Calabresi
Journal:  J Physiol       Date:  2003-03-28       Impact factor: 5.182

4.  Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat.

Authors:  Lei Wang; Meredith A Albrecht; Richard J Wurtman
Journal:  Brain Res       Date:  2006-12-19       Impact factor: 3.252

Review 5.  Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.

Authors:  Sergi Ferré; Luigi F Agnati; Francisco Ciruela; Carme Lluis; Amina S Woods; Kjell Fuxe; Rafael Franco
Journal:  Brain Res Rev       Date:  2007-01-27

6.  Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

Authors:  T Miyakawa; M Yamada; A Duttaroy; J Wess
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

7.  The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum.

Authors:  Li Chen; Mallika Chatterjee; James Y H Li
Journal:  J Neurosci       Date:  2010-11-03       Impact factor: 6.167

Review 8.  Neurobiology of aversive states.

Authors:  Erin N Umberg; Emmanuel N Pothos
Journal:  Physiol Behav       Date:  2011-05-01

9.  Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.

Authors:  Yosuke Morishima; Tsuyoshi Miyakawa; Tomoyuki Furuyashiki; Yasuhiro Tanaka; Hiroshi Mizuma; Shigetada Nakanishi
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-07       Impact factor: 11.205

10.  Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.

Authors:  Takatoshi Hikida; Yasuji Kitabatake; Ira Pastan; Shigetada Nakanishi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-29       Impact factor: 11.205
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