| Literature DB >> 1091471 |
Abstract
The DNA synthesis of isolated pancreatic islets has been determined after culture in vitro of the islets for 5 days in media containing either various glucose concentrations or tolbutamide or cortisone. Only glucose stimulated the replication of DNA, while cortisone was inhibitory and tolbutamide without effect. It is concluded that glucose by itself stimulates the mitotic rate of the islet cells and that the corresponding effect of steroids in vivo may be mediated through the ensuing hyperglycemia.Entities:
Mesh：
Substances：
Year: 1975 PMID： 1091471 DOI： 10.1210/endo-96-4-1051
Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736