Literature DB >> 10914315

Potential applications of carbomer in oral mucoadhesive controlled drug delivery system: a review.

A K Singla1, M Chawla, A Singh.   

Abstract

Carbomers are extensively being used in controlled drug delivery systems (CDDS). They are also finding numerous applications in oral mucoadhesive drug delivery because of their ability to interact with the mucus glycoprotein and to remain localized to a specific site. The present review aims at giving an insight into the potential application of carbomers in mucoadhesive CDDS. This review deals with the physicochemical properties of carbomers and various mechanisms of mucoadhesion. The mechanism for the release of the drug, both water soluble and water insoluble, is discussed. The use of carbomers in oral delivery of peptides or protein-based drugs is also covered.

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Year:  2000        PMID： 10914315     DOI： 10.1081/ddc-100101318

Source DB:  PubMed          Journal:  Drug Dev Ind Pharm        ISSN： 0363-9045            Impact factor:   3.225


  25 in total

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Journal:  Pharm Res       Date:  2008-06       Impact factor: 4.200

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9.  Formulation study and evaluation of matrix and three-layer tablet sustained drug delivery systems based on Carbopols with isosorbite mononitrate.

Authors:  M Efentakis; C Peponaki
Journal:  AAPS PharmSciTech       Date:  2008-08-07       Impact factor: 3.246

10.  Combination Adjuvants Affect the Magnitude of Effector-Like Memory CD8 T Cells and Protection against Listeriosis.

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