Literature DB >> 10913934

Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems.

D L Medina1, P Santisteban.   

Abstract

This review is focused on the most recent knowledge on growth control of rat thyroid cell lines. We analyzed the effect of mitogenic as well as inhibitory agents, but mainly the proliferative effect elicited by thyrotropin (TSH). The classic cAMP-dependent protein kinase (PKA) signal transduction pathway involved in TSH-mediated cell growth is analyzed exhaustively. We have also reviewed new concepts about the participation of other effectors such as small GTPases and phosphatidyl inositol-3-kinase (PI3-K) and the new data about the existence of a cAMP-dependent but PKA-independent pathway. Finally, we give information about TSH induction of cell cycle-related genes, such as G1 cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors.

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Year:  2000        PMID： 10913934     DOI： 10.1530/eje.0.1430161

Source DB:  PubMed          Journal:  Eur J Endocrinol        ISSN： 0804-4643            Impact factor:   6.664


  29 in total

1.  HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.

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Review 2.  Thyroid development and effect on the nervous system.

Authors:  Pilar Santisteban; Juan Bernal
Journal:  Rev Endocr Metab Disord       Date:  2005-08       Impact factor: 6.514

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Review 4.  The glycerophosphoinositols: cellular metabolism and biological functions.

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Journal:  Cell Mol Life Sci       Date:  2009-08-09       Impact factor: 9.261

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Review 6.  The biology of the sodium iodide symporter and its potential for targeted gene delivery.

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7.  Biased signaling by thyroid-stimulating hormone receptor-specific antibodies determines thyrocyte survival in autoimmunity.

Authors:  Syed A Morshed; Risheng Ma; Rauf Latif; Terry F Davies
Journal:  Sci Signal       Date:  2018-01-23       Impact factor: 8.192

8.  G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway.

Authors:  Nathan C Law; Morris F White; Mary E Hunzicker-Dunn
Journal:  J Biol Chem       Date:  2016-11-17       Impact factor: 5.157

9.  Hypothyroidism and hyperthyroidism modulates Ras-MAPK intracellular pathway in rat thyroids.

Authors:  Anna Lúcia R C Leal; Thiago U Pantaleão; Débora G Moreira; Michelle P Marassi; Valmara S Pereira; Doris Rosenthal; Vânia Maria Corrêa da Costa
Journal:  Endocrine       Date:  2007-04       Impact factor: 3.633

10.  Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells.

Authors:  Miguel A Zaballos; Bibian Garcia; Pilar Santisteban
Journal:  Mol Endocrinol       Date:  2008-01-17
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