Literature DB >> 10913909

Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?

M E Nuttall1, J M Gimble.   

Abstract

Bone marrow stromal cells can undergo adipogenesis or osteoblastogenesis in vitro and in vivo. This review explores the stromal cell's differentiation plasticity in the context of osteoporosis and other metabolic bone disorders. Attention is focused on the apparent reciprocal relationship that is postulated to exist between the adipocyte and osteoblast phenotypes. The signal transduction pathways implicated in this process are evaluated as potential targets for therapeutic intervention and drug design.

Entities:  

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Year:  2000        PMID： 10913909     DOI： 10.1016/s8756-3282(00)00317-3

Source DB:  PubMed          Journal:  Bone        ISSN： 1873-2763            Impact factor:   4.398


  76 in total

1.  Effects of age on parathyroid hormone signaling in human marrow stromal cells.

Authors:  Shuanhu Zhou; Ericka M Bueno; Sung Won Kim; Ilaria Amato; Longxiang Shen; Jochen Hahne; Ilan Bleiberg; Paul Morley; Julie Glowacki
Journal:  Aging Cell       Date:  2011-05-25       Impact factor: 9.304

2.  Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis.

Authors:  Cristina C Teixeira; Yuexun Liu; Lwin M Thant; Jason Pang; Glyn Palmer; Mani Alikhani
Journal:  J Biol Chem       Date:  2010-07-22       Impact factor: 5.157

3.  Interaction between dietary conjugated linoleic acid and calcium supplementation affecting bone and fat mass.

Authors:  Yooheon Park; Michael Terk; Yeonhwa Park
Journal:  J Bone Miner Metab       Date:  2010-08-10       Impact factor: 2.626

4.  Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes.

Authors:  Lige Song; Minlin Liu; Noriaki Ono; F Richard Bringhurst; Henry M Kronenberg; Jun Guo
Journal:  J Bone Miner Res       Date:  2012-11       Impact factor: 6.741

5.  FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling.

Authors:  Chunhui Sun; Hebao Yuan; Li Wang; Xiaoxi Wei; Linford Williams; Paul H Krebsbach; Jun-Lin Guan; Fei Liu
Journal:  J Bone Miner Res       Date:  2016-10-24       Impact factor: 6.741

Review 6.  Mesenchymal stem cells: lineage, plasticity, and skeletal therapeutic potential.

Authors:  Richard O C Oreffo; Cyrus Cooper; Christopher Mason; Mark Clements
Journal:  Stem Cell Rev       Date:  2005       Impact factor: 5.739

7.  Terbium promotes adhesion and osteogenic differentiation of mesenchymal stem cells via activation of the Smad-dependent TGF-β/BMP signaling pathway.

Authors:  Dan-Dan Liu; Kun Ge; Yi Jin; Jing Sun; Shu-Xiang Wang; Meng-Su Yang; Jin-Chao Zhang
Journal:  J Biol Inorg Chem       Date:  2014-03-02       Impact factor: 3.358

8.  Bone marrow fat content in 70 adolescent girls with anorexia nervosa: Magnetic resonance imaging and magnetic resonance spectroscopy assessment.

Authors:  Kirsten Ecklund; Sridhar Vajapeyam; Robert V Mulkern; Henry A Feldman; Jennifer M O'Donnell; Amy D DiVasta; Catherine M Gordon
Journal:  Pediatr Radiol       Date:  2017-04-22

9.  Nuclear receptor profile in calvarial bone cells undergoing osteogenic versus adipogenic differentiation.

Authors:  Flavia Q Pirih; Rosette Abayahoudian; David Elashoff; Farhad Parhami; Jeanne M Nervina; Sotirios Tetradis
Journal:  J Cell Biochem       Date:  2008-12-01       Impact factor: 4.429

10.  Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways.

Authors:  Nan Li; Robert N Kelsh; Peter Croucher; Henry H Roehl
Journal:  Development       Date:  2010-02       Impact factor: 6.868
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