A survey of the use of post-exposure prophylaxis for occupational exposure to human immunodeficiency virus.

The objective of this study was to review the appropriateness of the use of post-HIV exposure prophylaxis for incidents involving occupational exposure to body fluids. The design was a retrospective analysis of the 32 incidents for which at least one dose of post-exposure prophylaxis was given, reported to the occupational health department of a London teaching hospital between 20 August 1997 and 20 January 1999. The main outcome measures were the proportion of prescriptions for exposure to a known HIV positive source, and criteria for prescribing when the source patient's HIV status was unknown. Only 31% of prescriptions were for exposure to a known HIV positive source. The reasons for prescribing post-exposure prophylaxis in the other 69% of cases were unclear. Safety data for short courses of anti-retroviral drugs in this setting could help to assess the appropriateness of their use to allay anxiety in healthcare workers, pending clarification of the source patient's HIV status. Closer collaboration between departments and more detailed guidance would improve consistency of practice, and may save some unnecessary prescriptions for expensive and toxic drugs.