C DeBattista1, J A Posener, B M Kalehzan, A F Schatzberg. 1. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5723, USA. debattista@leland-stanford.edu
Abstract
OBJECTIVE: The primary objective of this investigation was to examine the acute antidepressant effects of intravenous hydrocortisone and ovine corticotropin releasing hormone (CRH) infusions in patients with major depression. METHOD: Twenty-two patients who met DSM-III-R criteria for nonpsychotic major depression were randomly assigned to receive intravenously 1 mg/kg of ovine CRH, 15 mg of hydrocortisone, or saline under double-blind conditions on day 1. Standard depression rating scales were completed on day 1 before the study medications were administered and again the following day (day 2). RESULTS: Patients treated with hydrocortisone demonstrated a significantly greater reduction in total 21-item Hamilton Depression Rating Scale scores (mean reduction=8.4 points or 37%) than patients given ovine CRH (mean=1.2 points) or placebo (mean=1.3 points). CONCLUSIONS:Acute hydrocortisone infusion is associated with a rapid and robust reduction in depressive symptoms. The authors discuss the therapeutic implications of these findings.
RCT Entities:
OBJECTIVE: The primary objective of this investigation was to examine the acute antidepressant effects of intravenous hydrocortisone and ovine corticotropin releasing hormone (CRH) infusions in patients with major depression. METHOD: Twenty-two patients who met DSM-III-R criteria for nonpsychotic major depression were randomly assigned to receive intravenously 1 mg/kg of ovine CRH, 15 mg of hydrocortisone, or saline under double-blind conditions on day 1. Standard depression rating scales were completed on day 1 before the study medications were administered and again the following day (day 2). RESULTS:Patients treated with hydrocortisone demonstrated a significantly greater reduction in total 21-item Hamilton Depression Rating Scale scores (mean reduction=8.4 points or 37%) than patients given ovine CRH (mean=1.2 points) or placebo (mean=1.3 points). CONCLUSIONS: Acute hydrocortisone infusion is associated with a rapid and robust reduction in depressive symptoms. The authors discuss the therapeutic implications of these findings.
Authors: Cornelius Schüle; Thomas C Baghai; Daniela Eser; Peter Zwanzger; Martina Jordan; Renate Buechs; Rainer Rupprecht Journal: Psychopharmacology (Berl) Date: 2006-04-22 Impact factor: 4.530
Authors: Roma A Vasa; Daniel S Pine; Carrie L Masten; Meena Vythilingam; Carlos Collin; Dennis S Charney; Alexander Neumeister; Karin Mogg; Brendan P Bradley; Maggie Bruck; Christopher S Monk Journal: Psychopharmacology (Berl) Date: 2009-03-06 Impact factor: 4.530
Authors: Christoph Anacker; Patricia A Zunszain; Livia A Carvalho; Carmine M Pariante Journal: Psychoneuroendocrinology Date: 2011-04 Impact factor: 4.905
Authors: Carmine M Pariante; Andrew S Papadopoulos; Lucia Poon; Anthony J Cleare; Stuart A Checkley; Judie English; Robert W Kerwin; Stafford Lightman Journal: Psychopharmacology (Berl) Date: 2004-06-04 Impact factor: 4.530