| Literature DB >> 10910347 |
A J Simpson1, F C Reinach, P Arruda, F A Abreu, M Acencio, R Alvarenga, L M Alves, J E Araya, G S Baia, C S Baptista, M H Barros, E D Bonaccorsi, S Bordin, J M Bové, M R Briones, M R Bueno, A A Camargo, L E Camargo, D M Carraro, H Carrer, N B Colauto, C Colombo, F F Costa, M C Costa, C M Costa-Neto, L L Coutinho, M Cristofani, E Dias-Neto, C Docena, H El-Dorry, A P Facincani, A J Ferreira, V C Ferreira, J A Ferro, J S Fraga, S C França, M C Franco, M Frohme, L R Furlan, M Garnier, G H Goldman, M H Goldman, S L Gomes, A Gruber, P L Ho, J D Hoheisel, M L Junqueira, E L Kemper, J P Kitajima, J E Krieger, E E Kuramae, F Laigret, M R Lambais, L C Leite, E G Lemos, M V Lemos, S A Lopes, C R Lopes, J A Machado, M A Machado, A M Madeira, H M Madeira, C L Marino, M V Marques, E A Martins, E M Martins, A Y Matsukuma, C F Menck, E C Miracca, C Y Miyaki, C B Monteriro-Vitorello, D H Moon, M A Nagai, A L Nascimento, L E Netto, A Nhani, F G Nobrega, L R Nunes, M A Oliveira, M C de Oliveira, R C de Oliveira, D A Palmieri, A Paris, B R Peixoto, G A Pereira, H A Pereira, J B Pesquero, R B Quaggio, P G Roberto, V Rodrigues, A J de M Rosa, V E de Rosa, R G de Sá, R V Santelli, H E Sawasaki, A C da Silva, A M da Silva, F R da Silva, W A da Silva, J F da Silveira, M L Silvestri, W J Siqueira, A A de Souza, A P de Souza, M F Terenzi, D Truffi, S M Tsai, M H Tsuhako, H Vallada, M A Van Sluys, S Verjovski-Almeida, A L Vettore, M A Zago, M Zatz, J Meidanis, J C Setubal.
Abstract
Xylella fastidiosa is a fastidious, xylem-limited bacterium that causes a range of economically important plant diseases. Here we report the complete genome sequence of X. fastidiosa clone 9a5c, which causes citrus variegated chlorosis--a serious disease of orange trees. The genome comprises a 52.7% GC-rich 2,679,305-base-pair (bp) circular chromosome and two plasmids of 51,158 bp and 1,285 bp. We can assign putative functions to 47% of the 2,904 predicted coding regions. Efficient metabolic functions are predicted, with sugars as the principal energy and carbon source, supporting existence in the nutrient-poor xylem sap. The mechanisms associated with pathogenicity and virulence involve toxins, antibiotics and ion sequestration systems, as well as bacterium-bacterium and bacterium-host interactions mediated by a range of proteins. Orthologues of some of these proteins have only been identified in animal and human pathogens; their presence in X. fastidiosa indicates that the molecular basis for bacterial pathogenicity is both conserved and independent of host. At least 83 genes are bacteriophage-derived and include virulence-associated genes from other bacteria, providing direct evidence of phage-mediated horizontal gene transfer.Entities:
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Year: 2000 PMID： 10910347 DOI： 10.1038/35018003
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962