Literature DB >> 10909277

Cytotoxic triterpenes from stem bark of Physocarpus intermedius.

Y K Kim, S K Yoon, S Y Ryu.   

Abstract

Seven triterpenes (1-7), i.e., betulinic acid 1, ursolic acid 2, oleanolic acid 3, 3-O-caffeoyloleanolic acid 4, euscaphic acid 5, 2 alpha-hydroxyursolic acid 6 and maslinic acid 7 were isolated from the stem bark extract of P. intermedius as active principles responsible for the cytotoxicity against five cultured human tumor cell lines, i.e., A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.

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Year:  2000        PMID： 10909277     DOI： 10.1055/s-2000-8585

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

Review 1.  Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).

Authors:  Anita M Brinker; Jun Ma; Peter E Lipsky; Ilya Raskin
Journal:  Phytochemistry       Date:  2007-01-23       Impact factor: 4.072

2.  Calenduloside E 6'-methyl ester induces apoptosis in CT-26 mouse colon carcinoma cells and inhibits tumor growth in a CT-26 xenograft animal model.

Authors:  Bora Lee; Dae Young Lee; Ki Hyun Yoo; Nam In Baek; Jong-Hwa Park; In Sik Chung
Journal:  Oncol Lett       Date:  2012-04-24       Impact factor: 2.967

3.  Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties.

Authors:  Andrew T Nelson; Andrew M Camelio; Karin R Claussen; Jiyoon Cho; Lisa Tremmel; John DiGiovanni; Dionicio Siegel
Journal:  Bioorg Med Chem Lett       Date:  2015-07-22       Impact factor: 2.823

4.  Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo.

Authors:  Kelly Araújo Lúcio; Gleice da Graça Rocha; Leonardo Campos Monção-Ribeiro; Janaina Fernandes; Christina Maeda Takiya; Cerli Rocha Gattass
Journal:  PLoS One       Date:  2011-12-09       Impact factor: 3.240

5.  In Vitro Evaluation of the Antimicrobial Ability and Cytotoxicity on Two Melanoma Cell Lines of a Benzylamide Derivative of Maslinic Acid.

Authors:  Ioana Zinuca Pavel; Corina Danciu; Camelia Oprean; Cristina Adriana Dehelean; Delia Muntean; René Csuk; Danina Mirela Muntean
Journal:  Anal Cell Pathol (Amst)       Date:  2016-12-05       Impact factor: 2.916

6.  Betulinic Acid Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis.

Authors:  Dahae Lee; Seoung Rak Lee; Ki Sung Kang; Yuri Ko; Changhyun Pang; Noriko Yamabe; Ki Hyun Kim
Journal:  Biomolecules       Date:  2019-07-03

7.  Evaluation of antimicrobial activity of extracts of Tibouchina candolleana (melastomataceae), isolated compounds and semi-synthetic derivatives against endodontic bacteria.

Authors:  Fernanda M Dos Santos; Maria Gorete de Souza; Antônio E Miller Crotti; Carlos H G Martins; Sérgio R Ambrósio; Rodrigo C S Veneziani; Márcio L Andrade E Silva; Wilson R Cunha
Journal:  Braz J Microbiol       Date:  2012-06-01       Impact factor: 2.476

8.  Oleanolic acid inhibits proliferation and induces apoptosis in NB4 cells by targeting PML/RARα

Authors:  Hongmei Li; Ning He; Xueyan Li; Li Zhou; Mingyu Zhao; Hairui Jiang; Xiaojie Zhang
Journal:  Oncol Lett       Date:  2013-07-29       Impact factor: 2.967

9.  Unveiling the Differential Antioxidant Activity of Maslinic Acid in Murine Melanoma Cells and in Rat Embryonic Healthy Cells Following Treatment with Hydrogen Peroxide.

Authors:  Khalida Mokhtari; Amalia Pérez-Jiménez; Leticia García-Salguero; José A Lupiáñez; Eva E Rufino-Palomares
Journal:  Molecules       Date:  2020-09-03       Impact factor: 4.411
  9 in total

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