Literature DB >> 10907730

Reduction of dyskinesia and induction of akinesia induced by morphine in two parkinsonian patients with severe sciatica.

D Berg1, G Becker, K Reiners.   

Abstract

In two patients with Parkinson's disease and L-Dopa induced dyskinesia we administered morphine orally to alleviate lumboradicular pain unresponsive to any other form of treatment. Besides an alleviation of the pain both patients showed a decrease in dyskinetic movements at very low doses of morphine and an increase in akinesia at higher doses. This observation indicates a modulation of basal ganglia output by morphine with the possibility of reducing L-Dopa induced dyskinesia in patients treated with morphine for pain.

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Year:  1999        PMID： 10907730     DOI： 10.1007/s007020050192

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  13 in total

1.  [Temporary suppression of tremor by remifentanil in a patient with Parkinson's disease during cataract extraction under local anesthesia].

Authors:  W Böhmdorfer; Ph Schwarzinger; S Binder; P Sporn
Journal:  Anaesthesist       Date:  2003-09       Impact factor: 1.041

2.  Dual κ-agonist/μ-antagonist opioid receptor modulation reduces levodopa-induced dyskinesia and corrects dysregulated striatal changes in the nonhuman primate model of Parkinson disease.

Authors:  Lisa F Potts; Eun S Park; Jong-Min Woo; Bhagya L Dyavar Shetty; Arun Singh; Steven P Braithwaite; Michael Voronkov; Stella M Papa; M Maral Mouradian
Journal:  Ann Neurol       Date:  2015-03-27       Impact factor: 10.422

Review 3.  Pains in Parkinson disease--many syndromes under one umbrella.

Authors:  Gunnar Wasner; Günther Deuschl
Journal:  Nat Rev Neurol       Date:  2012-04-17       Impact factor: 42.937

4.  Efficacy and safety profile of prolonged release oxycodone in combination with naloxone (OXN PR) in Parkinson's disease patients with chronic pain.

Authors:  Graziella Madeo; Tommaso Schirinzi; Silvia Natoli; Mariangela Pierantozzi; Alessandro Stefani; Mario Dauri; Antonio Pisani
Journal:  J Neurol       Date:  2015-07-02       Impact factor: 4.849

5.  Presynaptic modulation of synaptic transmission by opioid receptor in rat subthalamic nucleus in vitro.

Authors:  Ke-Zhong Shen; Steven W Johnson
Journal:  J Physiol       Date:  2002-05-15       Impact factor: 5.182

6.  The selective kappa-opioid receptor agonist U50,488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates.

Authors:  Heather Cox; Daniel M Togasaki; Li Chen; J William Langston; Donato A Di Monte; Maryka Quik
Journal:  Exp Neurol       Date:  2007-02-03       Impact factor: 5.330

Review 7.  [Parkinson's disease. Perioperative management and anesthesia].

Authors:  U Wüllner; J Standop; O Kaut; V Coenen; A Kalenka; F Wappler
Journal:  Anaesthesist       Date:  2012-02       Impact factor: 1.041

Review 8.  Anaesthesia in elderly patients with neurodegenerative disorders: special considerations.

Authors:  Deborah A Burton; Grainne Nicholson; George M Hall
Journal:  Drugs Aging       Date:  2004       Impact factor: 3.923

Review 9.  Dopamine, morphine, and nitric oxide: an evolutionary signaling triad.

Authors:  George B Stefano; Richard M Kream
Journal:  CNS Neurosci Ther       Date:  2009-11-13       Impact factor: 5.243

10.  [Lumbar back pain in patients with Parkinson's disease].

Authors:  O Rommel; D Wejwer; K Schybek; T Przybilski; G Jäger; S Gräber; D Berg
Journal:  Nervenarzt       Date:  2016-04       Impact factor: 1.214
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