Literature DB >> 10906513

Program for testing biological interventions to promote healthy aging.

H R Warner1, D Ingram, R A Miller, N L Nadon, A G Richardson.   

Abstract

The National Institute on Aging (NIA) sponsored a workshop on September, 1999 to discuss the feasibility of establishing a program to evaluate potential intervention strategies to decelerate the rate of aging in mammals. The ultimate goal is to identify promising interventions in animals that might lead to clinical trials in humans. The participants discussed various animal models, biological endpoints and possible structure of such a program. The ability to implement such a program will require a decision by NIA staff about whether the anticipated benefits to be derived from identification of effective interventions under well controlled conditions in an animal model, in this case the mouse, would justify the anticipated cost of the testing program.

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Year:  2000        PMID: 10906513     DOI: 10.1016/s0047-6374(00)00118-4

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN: 0047-6374            Impact factor:   5.432


  23 in total

Review 1.  Calorie restriction: what recent results suggest for the future of ageing research.

Authors:  Daniel L Smith; Tim R Nagy; David B Allison
Journal:  Eur J Clin Invest       Date:  2010-05       Impact factor: 4.686

2.  Profiling psychomotor and cognitive aging in four-way cross mice.

Authors:  Nathalie Sumien; Micaela N Sims; Hilary J Taylor; Michael J Forster
Journal:  Age (Dordr)       Date:  2006-11-25

Review 3.  Are sirtuins viable targets for improving healthspan and lifespan?

Authors:  Joseph A Baur; Zoltan Ungvari; Robin K Minor; David G Le Couteur; Rafael de Cabo
Journal:  Nat Rev Drug Discov       Date:  2012-06-01       Impact factor: 84.694

4.  National Institute on Aging at middle age--its past, present, and future.

Authors:  Catherine L Nagy; Marie A Bernard; Richard J Hodes
Journal:  J Am Geriatr Soc       Date:  2012-05-30       Impact factor: 5.562

5.  Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Authors:  Richard A Miller; David E Harrison; C M Astle; Joseph A Baur; Angela Rodriguez Boyd; Rafael de Cabo; Elizabeth Fernandez; Kevin Flurkey; Martin A Javors; James F Nelson; Carlos J Orihuela; Scott Pletcher; Zelton Dave Sharp; David Sinclair; Joseph W Starnes; J Erby Wilkinson; Nancy L Nadon; Randy Strong
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-10-25       Impact factor: 6.053

6.  Design of aging intervention studies: the NIA interventions testing program.

Authors:  N L Nadon; R Strong; R A Miller; J Nelson; M Javors; Z D Sharp; J M Peralba; D E Harrison
Journal:  Age (Dordr)       Date:  2008-04-18

Review 7.  Nutrition, metabolism, and targeting aging in nonhuman primates.

Authors:  Priya Balasubramanian; Julie A Mattison; Rozalyn M Anderson
Journal:  Ageing Res Rev       Date:  2017-02-20       Impact factor: 10.895

8.  NIA's Intervention Testing Program at 10 years of age.

Authors:  Huber R Warner
Journal:  Age (Dordr)       Date:  2015-03-01

9.  Geroscience and the trans-NIH Geroscience Interest Group, GSIG.

Authors:  Felipe Sierra; Ron Kohanski
Journal:  Geroscience       Date:  2017-02       Impact factor: 7.713

10.  Translational Geroscience: From invertebrate models to companion animal and human interventions.

Authors:  Mitchell B Lee; Matt Kaeberlein
Journal:  Transl Med Aging       Date:  2018-08-17
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