Literature DB >> 10906415

Design and synthesis of alpha,beta-unsaturated carbonyl compounds as potential ACE inhibitors.

H Y Park Choo1, K H Peak, J Park, D H Kim, H S Chung.   

Abstract

The alpha,beta-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly.

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Year:  2000        PMID： 10906415     DOI： 10.1016/s0223-5234(00)00158-6

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  2 in total

1.  Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus.

Authors:  Daniel Kalb; Thorsten Heinekamp; Gerald Lackner; Daniel H Scharf; Hans-Martin Dahse; Axel A Brakhage; Dirk Hoffmeister
Journal:  Appl Environ Microbiol       Date:  2014-12-19       Impact factor: 4.792

2.  Some chalcones derived from thio-phene-3-carbaldehyde: synthesis and crystal structures.

Authors:  Trung Vu Quoc; Duong Tran Thi Thuy; Thuan Dang Thanh; Thanh Phung Ngoc; Vuong Nguyen Thien; Chinh Nguyen Thuy; Luc Van Meervelt
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-06-04
  2 in total

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