METHODS: A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction. RESULTS: Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B. CONCLUSION: These data suggest that HHV-7 may invade the CNS.
METHODS: A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction. RESULTS: Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B. CONCLUSION: These data suggest that HHV-7 may invade the CNS.
Authors: J S van den Berg; J H van Zeijl; J J Rotteveel; W J Melchers; F J Gabreëls; J M Galama Journal: Neurology Date: 1999-03-23 Impact factor: 9.910
Authors: S Suga; T Yoshikawa; Y Asano; T Kozawa; T Nakashima; I Kobayashi; T Yazaki; H Yamamoto; Y Kajita; T Ozaki Journal: Ann Neurol Date: 1993-06 Impact factor: 10.422
Authors: T Yoshikawa; T Nakashima; S Suga; Y Asano; T Yazaki; H Kimura; T Morishima; K Kondo; K Yamanishi Journal: Pediatrics Date: 1992-05 Impact factor: 7.124