Literature DB >> 10905996

Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats.

H Jänkälä1, N E Petersen, M Härkönen, T Mäki.   

Abstract

We studied the effects of ethanol and acetaldehyde on myocardial gene expression of atrial natriuretic peptide (ANP) and growth of rats. Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40-60% in 2-8 day experiments, compared to the controls. The results suggest a role for acetaldehyde in the development of alcoholic heart dysfunction.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10905996     DOI： 10.1093/alcalc/35.4.331

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN： 0735-0414            Impact factor:   2.826


  2 in total

Review 1.  ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications.

Authors:  Yingmei Zhang; Jun Ren
Journal:  Pharmacol Ther       Date:  2011-06-12       Impact factor: 12.310

2.  Propranolol Is Associated with Lower Risk of Incidence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Tertiary-Center Study and Indirect Comparison with Meta-Analysis.

Authors:  Tzu-Hao Li; Yu-Lien Tsai; Chien-Fu Hsu; Chih-Wei Liu; Chia-Chang Huang; Ying-Ying Yang; Hung-Cheng Tsai; Shiang-Fen Huang; Yun-Cheng Hsieh; Hsuan-Miao Liu; Tzung-Yan Lee; Ming-Chih Hou; Chang-Youh Tsai; Han-Chieh Lin
Journal:  Gastroenterol Res Pract       Date:  2020-04-09       Impact factor: 2.260
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.