Literature DB >> 10905630

Lipid acetylation reactions and the metabolism of platelet-activating factor.

R R Baker1.   

Abstract

In this review properties of lipid acetyltransferase enzymes are outlined. The three activities of interest are lyso PAF acetyltransferase (acetyl CoA: 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase), AGP acetyltransferase (acetyl CoA: 1-alkyl sn-glycero-3-phosphate acetyltransferase) and a transacetylase activity that can transfer acetyl groups from PAF to lipid acceptors in the formation of 1-alkenyl-2-acetyl-sn-glycero-3-phosphoethanolamine and N-acetyl sphingosine (C2 ceramide). This review focuses on the role of acetyltransferases and transacetylases within the metabolism of platelet-activating factor and specifically addresses characteristics of the enzymes, including subcellular localization, substrate selectivity, and enzymatic regulation.

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Year:  2000        PMID： 10905630     DOI： 10.1023/a:1007567205078

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  67 in total

1.  1-alkyl-2-lyso-sn-glycero-3-phosphate acetyltransferase.

Authors:  F Snyder; T C Lee; B Malone
Journal:  Methods Enzymol       Date:  1992       Impact factor: 1.600

2.  Lysophosphatidic acid, alkylglycerophosphate and alkylacetylglycerophosphate increase the neuronal nuclear acetylation of 1-acyl lysophosphatidyl choline by inhibition of lysophospholipase.

Authors:  R R Baker; H Y Chang
Journal:  Mol Cell Biochem       Date:  1999-08       Impact factor: 3.396

3.  Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application.

Authors:  E Uhl; S Pickelmann; A Baethmann; L Schürer
Journal:  Stroke       Date:  1999-04       Impact factor: 7.914

4.  Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide.

Authors:  K Karasawa; X Qiu; T Lee
Journal:  J Biol Chem       Date:  1999-03-26       Impact factor: 5.157

5.  [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine].

Authors:  J Benveniste; M Tencé; P Varenne; J Bidault; C Boullet; J Polonsky
Journal:  C R Seances Acad Sci D       Date:  1979-11-26

6.  Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis.

Authors:  L Callea; M Arese; A Orlandini; C Bargnani; A Priori; F Bussolino
Journal:  J Neuroimmunol       Date:  1999-02-01       Impact factor: 3.478

7.  Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase.

Authors:  A B Nixon; J T O'Flaherty; J K Salyer; R L Wykle
Journal:  J Biol Chem       Date:  1999-02-26       Impact factor: 5.157

8.  Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase.

Authors:  L D Faison; H L White
Journal:  Prostaglandins       Date:  1992-09

9.  A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells.

Authors:  T C Lee; Y Uemura; F Snyder
Journal:  J Biol Chem       Date:  1992-10-05       Impact factor: 5.157

10.  Activation of the acetyl-coenzyme A:lysoplatelet-activating factor acetyltransferase regulates platelet-activating factor synthesis in human endothelial cells.

Authors:  M R Holland; M E Venable; R E Whatley; G A Zimmerman; T M McIntyre; S M Prescott
Journal:  J Biol Chem       Date:  1992-11-15       Impact factor: 5.157
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  2 in total

1.  Acetylation suppresses the proapoptotic activity of GD3 ganglioside.

Authors:  Florence Malisan; Luigi Franchi; Barbara Tomassini; Natascia Ventura; Ivano Condò; Maria Rita Rippo; Alessandra Rufini; Laura Liberati; Claudia Nachtigall; Bernhard Kniep; Roberto Testi
Journal:  J Exp Med       Date:  2002-12-16       Impact factor: 14.307

2.  X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure.

Authors:  Caroline E O'Riordan; Gareth S D Purvis; Debora Collotta; Nadine Krieg; Bianka Wissuwa; Madeeha H Sheikh; Gustavo Ferreira Alves; Shireen Mohammad; Lauren A Callender; Sina M Coldewey; Massimo Collino; David R Greaves; Christoph Thiemermann
Journal:  Front Immunol       Date:  2020-10-07       Impact factor: 7.561
  2 in total

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