Literature DB >> 10905250

Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease.

E Adalsteinsson, E V Sullivan, N Kleinhans, D M Spielman, A Pfefferbaum.   

Abstract

In patients with Alzheimer's disease, but not in health controls, longitudinal magnetic resonance spectroscopy shows a striking decline in the neuronal marker, N-acetyl aspartate, despite little decline in underlying grey-matter volume.

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Year:  2000        PMID： 10905250     DOI： 10.1016/s0140-6736(00)02246-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  47 in total

1.  Neurometabolites and associations with cognitive deficits in mild cognitive impairment: a magnetic resonance spectroscopy study at 7 Tesla.

Authors:  Georg Oeltzschner; S Andrea Wijtenburg; Mark Mikkelsen; Richard A E Edden; Peter B Barker; Jin Hui Joo; Jeannie-Marie S Leoutsakos; Laura M Rowland; Clifford I Workman; Gwenn S Smith
Journal:  Neurobiol Aging       Date:  2018-09-27       Impact factor: 4.673

Review 2.  Differential aging of the brain: patterns, cognitive correlates and modifiers.

Authors:  Naftali Raz; Karen M Rodrigue
Journal:  Neurosci Biobehav Rev       Date:  2006-08-17       Impact factor: 8.989

3.  Newfound effect of N-acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro.

Authors:  Jean-Pierre Dollé; Jeffrey M Rodgers; Kevin D Browne; Thomas Troxler; Feng Gai; Douglas H Smith
Journal:  Neurobiol Dis       Date:  2018-05-31       Impact factor: 5.996

Review 4.  Quantitative magnetic resonance techniques as surrogate markers of Alzheimer's disease.

Authors:  Kejal Kantarci; Clifford R Jack
Journal:  NeuroRx       Date:  2004-04

5.  Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.

Authors:  Itamar Ronen; Xiaoying Fan; Steve Schettler; Sahil Jain; Donna Murray; Dae-Shik Kim; Ronald Killiany; Douglas Rosene
Journal:  Neurobiol Aging       Date:  2009-06-27       Impact factor: 4.673

Review 6.  The clinical use of structural MRI in Alzheimer disease.

Authors:  Giovanni B Frisoni; Nick C Fox; Clifford R Jack; Philip Scheltens; Paul M Thompson
Journal:  Nat Rev Neurol       Date:  2010-02       Impact factor: 42.937

7.  Alzheimer disease: postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurements.

Authors:  Kejal Kantarci; David S Knopman; Dennis W Dickson; Joseph E Parisi; Jennifer L Whitwell; Stephen D Weigand; Keith A Josephs; Bradley F Boeve; Ronald C Petersen; Clifford R Jack
Journal:  Radiology       Date:  2008-07       Impact factor: 11.105

8.  Single-voxel (1)H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility.

Authors:  Najib Allaïli; Romain Valabrègue; Edward J Auerbach; Vincent Guillemot; Lydia Yahia-Cherif; Eric Bardinet; Maritza Jabourian; Philippe Fossati; Stéphane Lehéricy; Małgorzata Marjańska
Journal:  NMR Biomed       Date:  2015-08-18       Impact factor: 4.044

9.  Variation in longitudinal trajectories of regional brain volumes of healthy men and women (ages 10 to 85 years) measured with atlas-based parcellation of MRI.

Authors:  Adolf Pfefferbaum; Torsten Rohlfing; Margaret J Rosenbloom; Weiwei Chu; Ian M Colrain; Edith V Sullivan
Journal:  Neuroimage       Date:  2012-10-12       Impact factor: 6.556

10.  Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.

Authors:  Nicolas Fayed; Javier Garcia-Campayo; Rosa Magallón; Helena Andrés-Bergareche; Juan V Luciano; Eva Andres; Julián Beltrán
Journal:  Arthritis Res Ther       Date:  2010-07-07       Impact factor: 5.156
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