Literature DB >> 10904068

Detailed flow patterns in the nasal cavity.

J T Kelly1, A K Prasad, A S Wexler.   

Abstract

The human nasal cavity filters and conditions inspired air while providing olfactory function. Detailed experimental study of nasal airflow patterns has been limited because of the complex geometry of the nasal cavity. In this work, particle image velocimetry was used to determine two-dimensional instantaneous velocity vector fields in parallel planes throughout a model of the nasal cavity that was subjected to a nonoscillatory flow rate of 125 ml/s. The model, which was fabricated from 26 computed tomography scans by using rapid prototyping techniques, is a scaled replica of a human right nasal cavity. The resulting vector plots show that the flow is laminar and regions of highest velocity are in the nasal valve and in the inferior airway. The relatively low flow in the olfactory region appears to protect the olfactory bulb from particulate pollutants. Low flows were also observed in the nasal meatuses, whose primary function has been the subject of debate. Comparison of sequentially recorded data suggests a steady flow.

Entities:  

Mesh:

Year:  2000        PMID: 10904068     DOI: 10.1152/jappl.2000.89.1.323

Source DB:  PubMed          Journal:  J Appl Physiol (1985)        ISSN: 0161-7567


  39 in total

1.  Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb.

Authors:  Fuqiang Xu; Nian Liu; Ikuhiro Kida; Douglas L Rothman; Fahmeed Hyder; Gordon M Shepherd
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-08       Impact factor: 11.205

2.  Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: a preliminary report.

Authors:  Julia S Kimbell; Guilherme J M Garcia; Dennis O Frank; Daniel E Cannon; Sachin S Pawar; John S Rhee
Journal:  Am J Rhinol Allergy       Date:  2012 May-Jun       Impact factor: 2.467

3.  First Steps to Develop and Validate a CFPD Model in Order to Support the Design of Nose-to-Brain Delivered Biopharmaceuticals.

Authors:  Lucas Engelhardt; Martina Röhm; Chrystelle Mavoungou; Katharina Schindowski; Annette Schafmeister; Ulrich Simon
Journal:  Pharm Res       Date:  2016-02-17       Impact factor: 4.200

4.  Normative ranges of nasal airflow variables in healthy adults.

Authors:  Azadeh A T Borojeni; Guilherme J M Garcia; Masoud Gh Moghaddam; Dennis O Frank-Ito; Julia S Kimbell; Purushottam W Laud; Lisa J Koenig; John S Rhee
Journal:  Int J Comput Assist Radiol Surg       Date:  2019-07-02       Impact factor: 2.924

5.  Inflow boundary profile prescription for numerical simulation of nasal airflow.

Authors:  D J Taylor; D J Doorly; R C Schroter
Journal:  J R Soc Interface       Date:  2009-09-09       Impact factor: 4.118

6.  Virtual septoplasty: a method to predict surgical outcomes for patients with nasal airway obstruction.

Authors:  Masoud Gh Moghaddam; Guilherme J M Garcia; Dennis O Frank-Ito; Julia S Kimbell; John S Rhee
Journal:  Int J Comput Assist Radiol Surg       Date:  2020-02-20       Impact factor: 2.924

7.  On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation.

Authors:  Saikat Basu; Dennis O Frank-Ito; Julia S Kimbell
Journal:  Int J Numer Method Biomed Eng       Date:  2018-01-18       Impact factor: 2.747

8.  Computational fluid dynamics as surgical planning tool: a pilot study on middle turbinate resection.

Authors:  Kai Zhao; Prashant Malhotra; David Rosen; Pamela Dalton; Edmund A Pribitkin
Journal:  Anat Rec (Hoboken)       Date:  2014-11       Impact factor: 2.064

9.  The fluid dynamics of canine olfaction: unique nasal airflow patterns as an explanation of macrosmia.

Authors:  Brent A Craven; Eric G Paterson; Gary S Settles
Journal:  J R Soc Interface       Date:  2009-12-09       Impact factor: 4.118

10.  Creation of an idealized nasopharynx geometry for accurate computational fluid dynamics simulations of nasal airflow in patient-specific models lacking the nasopharynx anatomy.

Authors:  Azadeh A T Borojeni; Dennis O Frank-Ito; Julia S Kimbell; John S Rhee; Guilherme J M Garcia
Journal:  Int J Numer Method Biomed Eng       Date:  2016-09-21       Impact factor: 2.747

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.